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- W2090392605 endingPage "365" @default.
- W2090392605 startingPage "353" @default.
- W2090392605 abstract "The link between cytoskeletal actin dynamics and correlated gene activities was unclear. However, the discovery that globular actin polymerization liberates myocardin family transcriptional cofactors to induce serum response factor, which modulates the expression of genes encoding effectors of actin dynamics, has helped bridge this gap in our knowledge. Numerous physiological and pathological stimuli promote the rearrangement of the actin cytoskeleton, thereby modulating cellular motile functions. Although it seems intuitively obvious that cell motility requires coordinated protein biosynthesis, until recently the linkage between cytoskeletal actin dynamics and correlated gene activities remained unknown. This knowledge gap was filled in part by the discovery that globular actin polymerization liberates myocardin-related transcription factor (MRTF) cofactors, thereby inducing the nuclear transcription factor serum response factor (SRF) to modulate the expression of genes encoding structural and regulatory effectors of actin dynamics. This insight stimulated research to better understand the actin–MRTF–SRF circuit and to identify alternative mechanisms that link cytoskeletal dynamics and genome activity." @default.
- W2090392605 created "2016-06-24" @default.
- W2090392605 creator A5068872608 @default.
- W2090392605 creator A5084182062 @default.
- W2090392605 date "2010-05-01" @default.
- W2090392605 modified "2023-10-10" @default.
- W2090392605 title "Linking actin dynamics and gene transcription to drive cellular motile functions" @default.
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