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• W2090395060 abstract "2H solid-state nuclear magnetic resonance (SSNMR) spectra of 1-palmitoyl-d31-2-oleoyl-sn-glycero-3-phosphatidylcholine (POPC_ d31) in the mixture of PG-1 and POPC_d31 lipids deposited on thin cover-glass plates. The experimental line shapes of anisotropic 2 H SSNMR spectra measured at various peptide-to-lipid (P/L) ratios were simulated reasonably by assuming the mosaic spread of bilayers containing pore structures or the coexistence of the mosaic spread of bilayers and a fast-tumbling isotropic phase. Within a few days of incubation in the hydration chamber, the pores were formed by the peptide in the POPC_d31 and POPC_d31/cholesterol membranes. However, the formation of the pores was not clear in the POPC_d31/1-palmitoyl-2-oleoyl-sn-glycero-3-phosphatidylglycerol (POPG) membrane. Over a hundred days after hydration, a rapidly rotating isotropic phase increased in the POPC_d31 and the POPC_d31/cholesterol membranes with the higher P/L ratios, but no isotropic phase appeared in the POPC_d31/POPG membrane. Cholesterol added in the POPC bilayer acted as a stabilizer of the pore structure and suppressed the formation of a fast-tumbling isotropic phase." @default.
• W2090395060 created "2016-06-24" @default.
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• W2090395060 date "2010-02-20" @default.
• W2090395060 modified "2023-10-13" @default.
• W2090395060 title "An NMR Study on the Phase Change of Lipid Membranes by an Antimicrobial Peptide, Protegrin-1" @default.
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• W2090395060 doi "https://doi.org/10.5012/bkcs.2010.31.02.372" @default.
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