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• W2090398996 abstract "Maternal infection during pregnancy is associated with increased risk for neurodevelopmental disorders. Lipopolysaccharide (LPS) or saline was administered to rats to model maternal infection, and levels of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in maternal plasma, placenta, amniotic fluid, fetal liver/spleen, fetal brain, and cerebral cortex after birth were determined by ELISA or semiquantitative Western blot analysis. BDNF expression was significantly increased in the fetal brain (p=0.039); NGF expression was significantly increased in neonatal cortex (p=0.0009). Neurotrophic factor expression was also altered in other tissues of the maternal-fetal unit. Abnormal expression of neurotrophic factors represents a potential mechanism through which maternal infection increases risk for neurodevelopmental disorders." @default.
• W2090398996 created "2016-06-24" @default.
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• W2090398996 date "2003-05-01" @default.
• W2090398996 modified "2023-09-27" @default.
• W2090398996 title "Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal–fetal unit of the rat" @default.
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• W2090398996 doi "https://doi.org/10.1016/s0165-5728(03)00095-x" @default.
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