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• W2090404461 abstract "Immunization with parasite antigens derived from the gut of adult Haemonchus contortus induces significant levels of protection against the parasite in sheep and goats. However, the mechanisms of immunity involved in this protection are not clear. Here, we investigate the requirement for CD4+ T lymphocytes in gut antigen-induced immunity against H. contortus. Gut antigen immunized animals were depleted (> 98%) of their CD4+ T lymphocytes in peripheral blood by intravenous injection of an anti-CD4 MoAb. Depletion in peripheral blood persisted for at least eight days, after which there was gradual recovery of CD4+ T lymphocytes. Serum antibody levels in gut antigen-immunized animals correlated significantly with worm parameters, suggesting a contribution by antibody to the immunity observed. By covariate analysis, using ELISA OD as the covariate, CD4+ T lymphocyte depletion was shown to partially abrogate immunity induced by gut antigen immunization, against challenge infection with H. contortus. The greatest effect of CD4+ T lymphocyte depletion was observed at 14 days post-infection with differences between CD4+ T lymphocyte depleted and intact animals less apparent between days 21 and 25. Collectively, our data indicate that CD4+ T lymphocytes contribute to immunity induced by gut antigens. Our results also suggest that antibody works synergistically with CD4+ T lymphocytes to confer this immunity." @default.
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• W2090404461 date "1997-10-01" @default.
• W2090404461 modified "2023-09-23" @default.
• W2090404461 title "CD4 ⁺ T lymphocytes contribute to protective immunity induced in sheep and goats by <i>Haemonchus contortus</i> gut antigens" @default.
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• W2090404461 doi "https://doi.org/10.1046/j.1365-3024.1997.d01-149.x" @default.
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