FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090408133> ?p ?o ?g. }

• W2090408133 endingPage "1358" @default.
• W2090408133 startingPage "1352" @default.
• W2090408133 abstract "In LQTS, β-blocker therapy is effective in reducing the risk of cardiac events (syncope, aborted cardiac arrest, sudden cardiac death). Limited studies have compared the efficacy of different β-blockers.The goal of this study was to compare the efficacy of different β-blockers in long QT syndrome (LQTS) and in genotype-positive patients with LQT1 and LQT2.The study included 1,530 patients from the Rochester, New York-based LQTS Registry who were prescribed common β-blockers (atenolol, metoprolol, propranolol, or nadolol). Time-dependent Cox regression analyses were used to compare the efficacy of different β-blockers with the risk of cardiac events in LQTS.Relative to being off β-blockers, the hazard ratios and 95% confidence intervals (CIs) for first cardiac events for atenolol, metoprolol, propranolol, and nadolol were 0.71 (0.50 to 1.01), 0.70 (0.43 to 1.15) 0.65 (0.46 to 0.90), and 0.51 (0.35 to 0.74), respectively. In LQT1, the risk reduction for first cardiac events was similar among the 4 β-blockers, but in LQT2, nadolol provided the only significant risk reduction (hazard ratio: 0.40 [0.16 to 0.98]). Among patients who had a prior cardiac event while taking β-blockers, efficacy for recurrent events differed by drug (p = 0.004), and propranolol was the least effective compared with the other β-blockers.Although the 4 β-blockers are equally effective in reducing the risk of a first cardiac event in LQTS, their efficacy differed by genotype; nadolol was the only β-blocker associated with a significant risk reduction in patients with LQT2. Patients experiencing cardiac events during β-blocker therapy are at high risk for subsequent cardiac events, and propranolol is the least effective drug in this high-risk group." @default.
• W2090408133 created "2016-06-24" @default.
• W2090408133 creator A5016234572 @default.
• W2090408133 creator A5057507865 @default.
• W2090408133 creator A5076422519 @default.
• W2090408133 creator A5077082770 @default.
• W2090408133 creator A5078194623 @default.
• W2090408133 date "2014-09-01" @default.
• W2090408133 modified "2023-10-17" @default.
• W2090408133 title "Efficacy of Different Beta-Blockers in the Treatment of Long QT Syndrome" @default.
• W2090408133 cites W1923440392 @default.
• W2090408133 cites W1967418231 @default.
• W2090408133 cites W1978509335 @default.
• W2090408133 cites W2000620739 @default.
• W2090408133 cites W2004894384 @default.
• W2090408133 cites W2019045599 @default.
• W2090408133 cites W2029433670 @default.
• W2090408133 cites W2031090633 @default.
• W2090408133 cites W2050895944 @default.
• W2090408133 cites W2083828684 @default.
• W2090408133 cites W2085558951 @default.
• W2090408133 cites W2091453055 @default.
• W2090408133 cites W2097912415 @default.
• W2090408133 cites W2108048271 @default.
• W2090408133 cites W2126428415 @default.
• W2090408133 cites W2133663070 @default.
• W2090408133 cites W2152496222 @default.
• W2090408133 cites W2156937709 @default.
• W2090408133 cites W2159701763 @default.
• W2090408133 cites W2169054045 @default.
• W2090408133 doi "https://doi.org/10.1016/j.jacc.2014.05.068" @default.
• W2090408133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25257637" @default.
• W2090408133 hasPublicationYear "2014" @default.
• W2090408133 type Work @default.
• W2090408133 sameAs 2090408133 @default.
• W2090408133 citedByCount "121" @default.
• W2090408133 countsByYear W20904081332014 @default.
• W2090408133 countsByYear W20904081332015 @default.
• W2090408133 countsByYear W20904081332016 @default.
• W2090408133 countsByYear W20904081332017 @default.
• W2090408133 countsByYear W20904081332018 @default.
• W2090408133 countsByYear W20904081332019 @default.
• W2090408133 countsByYear W20904081332020 @default.
• W2090408133 countsByYear W20904081332021 @default.
• W2090408133 countsByYear W20904081332022 @default.
• W2090408133 countsByYear W20904081332023 @default.
• W2090408133 crossrefType "journal-article" @default.
• W2090408133 hasAuthorship W2090408133A5016234572 @default.
• W2090408133 hasAuthorship W2090408133A5057507865 @default.
• W2090408133 hasAuthorship W2090408133A5076422519 @default.
• W2090408133 hasAuthorship W2090408133A5077082770 @default.
• W2090408133 hasAuthorship W2090408133A5078194623 @default.
• W2090408133 hasBestOaLocation W20904081331 @default.
• W2090408133 hasConcept C118441451 @default.
• W2090408133 hasConcept C126322002 @default.
• W2090408133 hasConcept C164705383 @default.
• W2090408133 hasConcept C207103383 @default.
• W2090408133 hasConcept C2775935837 @default.
• W2090408133 hasConcept C2776256041 @default.
• W2090408133 hasConcept C2776525901 @default.
• W2090408133 hasConcept C2778151854 @default.
• W2090408133 hasConcept C2779703243 @default.
• W2090408133 hasConcept C2781280847 @default.
• W2090408133 hasConcept C42219234 @default.
• W2090408133 hasConcept C44249647 @default.
• W2090408133 hasConcept C71924100 @default.
• W2090408133 hasConcept C84393581 @default.
• W2090408133 hasConceptScore W2090408133C118441451 @default.
• W2090408133 hasConceptScore W2090408133C126322002 @default.
• W2090408133 hasConceptScore W2090408133C164705383 @default.
• W2090408133 hasConceptScore W2090408133C207103383 @default.
• W2090408133 hasConceptScore W2090408133C2775935837 @default.
• W2090408133 hasConceptScore W2090408133C2776256041 @default.
• W2090408133 hasConceptScore W2090408133C2776525901 @default.
• W2090408133 hasConceptScore W2090408133C2778151854 @default.
• W2090408133 hasConceptScore W2090408133C2779703243 @default.
• W2090408133 hasConceptScore W2090408133C2781280847 @default.
• W2090408133 hasConceptScore W2090408133C42219234 @default.
• W2090408133 hasConceptScore W2090408133C44249647 @default.
• W2090408133 hasConceptScore W2090408133C71924100 @default.
• W2090408133 hasConceptScore W2090408133C84393581 @default.
• W2090408133 hasIssue "13" @default.
• W2090408133 hasLocation W20904081331 @default.
• W2090408133 hasLocation W20904081332 @default.
• W2090408133 hasOpenAccess W2090408133 @default.
• W2090408133 hasPrimaryLocation W20904081331 @default.
• W2090408133 hasRelatedWork W170072628 @default.
• W2090408133 hasRelatedWork W1972332324 @default.
• W2090408133 hasRelatedWork W1991074391 @default.
• W2090408133 hasRelatedWork W2012717452 @default.
• W2090408133 hasRelatedWork W2025891827 @default.
• W2090408133 hasRelatedWork W2028677081 @default.
• W2090408133 hasRelatedWork W2037506292 @default.
• W2090408133 hasRelatedWork W2119789083 @default.
• W2090408133 hasRelatedWork W2363489052 @default.
• W2090408133 hasRelatedWork W2416974087 @default.
• W2090408133 hasVolume "64" @default.
• W2090408133 isParatext "false" @default.

• next