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- W2090410010 abstract "It has been shown that relatively high doses of epinephrine (E) injected intraperitoneally (IP) produce hypophagia and conditioned taste aversion (CTA) in rats. We examined the possibility that E effects involve malaise. For this purpose, changes in saccharin preference induced by E injected IP (100 microg/kg) were determined after a previous administration of trimethobenzamide (TMB, 5 mg/kg), an antiemetic agent. E alone decreased saccharin preference by 54% (p < 0.01), but only by 16% (not significant) in the presence of TMB. In contrast, the injection of 75 or 100 microg/kg E reduced food intake by 50 and 85%, respectively (p < 0.01), regardless of previous injection of TMB. In conclusion, the results suggest that E-induced malaise is not the direct cause of the hypophagia it elicits." @default.
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- W2090410010 date "1997-11-01" @default.
- W2090410010 modified "2023-10-17" @default.
- W2090410010 title "Antiemetic Inhibits Conditioned Taste Aversion, But Not the Hypophagia Induced by Epinephrine" @default.
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- W2090410010 doi "https://doi.org/10.1016/s0031-9384(97)00190-x" @default.
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