FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090415718> ?p ?o ?g. }

• W2090415718 endingPage "461" @default.
• W2090415718 startingPage "450" @default.
• W2090415718 abstract "Transthyretin (TTR) amyloidoses comprise a wide spectrum of acquired and hereditary diseases triggered by extracellular deposition of toxic TTR aggregates in various organs. Despite recent advances regarding the elucidation of the molecular mechanisms underlying TTR misfolding and pathogenic self-assembly, there is still no effective therapy for treatment of these fatal disorders. Recently, the molecular tweezers, CLR01, has been reported to inhibit self-assembly and toxicity of different amyloidogenic proteins in vitro, including TTR, by interfering with hydrophobic and electrostatic interactions known to play an important role in the aggregation process. In addition, CLR01 showed therapeutic effects in animal models of Alzheimer's disease and Parkinson's disease. Here, we assessed the ability of CLR01 to modulate TTR misfolding and aggregation in cell culture and in an animal model. In cell culture assays we found that CLR01 inhibited TTR oligomerization in the conditioned medium and alleviated TTR-induced neurotoxicity by redirecting TTR aggregation into the formation of innocuous assemblies. To determine whether CLR01 was effective in vivo, we tested the compound in mice expressing TTR V30M, a model of familial amyloidotic polyneuropathy, which recapitulates the main pathological features of the human disease. Immunohistochemical and Western blot analyses showed a significant decrease in TTR burden in the gastrointestinal tract and the peripheral nervous system in mice treated with CLR01, with a concomitant reduction in aggregate-induced endoplasmic reticulum stress response, protein oxidation, and apoptosis. Taken together, our preclinical data suggest that CLR01 is a promising lead compound for development of innovative, disease-modifying therapy for TTR amyloidosis." @default.
• W2090415718 created "2016-06-24" @default.
• W2090415718 creator A5007187482 @default.
• W2090415718 creator A5013150457 @default.
• W2090415718 creator A5019152554 @default.
• W2090415718 creator A5021195219 @default.
• W2090415718 creator A5034905768 @default.
• W2090415718 creator A5034927209 @default.
• W2090415718 creator A5035774671 @default.
• W2090415718 creator A5073284191 @default.
• W2090415718 creator A5083494051 @default.
• W2090415718 date "2014-01-24" @default.
• W2090415718 modified "2023-09-26" @default.
• W2090415718 title "Molecular Tweezers Targeting Transthyretin Amyloidosis" @default.
• W2090415718 cites W1965464051 @default.
• W2090415718 cites W1967144890 @default.
• W2090415718 cites W1972566382 @default.
• W2090415718 cites W1973839411 @default.
• W2090415718 cites W1975799517 @default.
• W2090415718 cites W1979219069 @default.
• W2090415718 cites W1983287291 @default.
• W2090415718 cites W1984503507 @default.
• W2090415718 cites W1995319721 @default.
• W2090415718 cites W1995660753 @default.
• W2090415718 cites W2002900801 @default.
• W2090415718 cites W2009952365 @default.
• W2090415718 cites W2018146982 @default.
• W2090415718 cites W2030479389 @default.
• W2090415718 cites W2031971916 @default.
• W2090415718 cites W2041138673 @default.
• W2090415718 cites W2048940684 @default.
• W2090415718 cites W2062001639 @default.
• W2090415718 cites W2062642061 @default.
• W2090415718 cites W2064146660 @default.
• W2090415718 cites W2068884332 @default.
• W2090415718 cites W2068914902 @default.
• W2090415718 cites W2076654506 @default.
• W2090415718 cites W2081954759 @default.
• W2090415718 cites W2085354241 @default.
• W2090415718 cites W2094309420 @default.
• W2090415718 cites W2121963977 @default.
• W2090415718 cites W2124058105 @default.
• W2090415718 cites W2131597939 @default.
• W2090415718 cites W2133643437 @default.
• W2090415718 cites W2136363024 @default.
• W2090415718 cites W2137119117 @default.
• W2090415718 cites W2142822529 @default.
• W2090415718 cites W2147305697 @default.
• W2090415718 cites W2147646431 @default.
• W2090415718 cites W2198986897 @default.
• W2090415718 cites W259812801 @default.
• W2090415718 cites W30870368 @default.
• W2090415718 cites W4247392277 @default.
• W2090415718 doi "https://doi.org/10.1007/s13311-013-0256-8" @default.
• W2090415718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3996111" @default.
• W2090415718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24459092" @default.
• W2090415718 hasPublicationYear "2014" @default.
• W2090415718 type Work @default.
• W2090415718 sameAs 2090415718 @default.
• W2090415718 citedByCount "39" @default.
• W2090415718 countsByYear W20904157182014 @default.
• W2090415718 countsByYear W20904157182015 @default.
• W2090415718 countsByYear W20904157182016 @default.
• W2090415718 countsByYear W20904157182017 @default.
• W2090415718 countsByYear W20904157182018 @default.
• W2090415718 countsByYear W20904157182019 @default.
• W2090415718 countsByYear W20904157182020 @default.
• W2090415718 countsByYear W20904157182021 @default.
• W2090415718 countsByYear W20904157182022 @default.
• W2090415718 countsByYear W20904157182023 @default.
• W2090415718 crossrefType "journal-article" @default.
• W2090415718 hasAuthorship W2090415718A5007187482 @default.
• W2090415718 hasAuthorship W2090415718A5013150457 @default.
• W2090415718 hasAuthorship W2090415718A5019152554 @default.
• W2090415718 hasAuthorship W2090415718A5021195219 @default.
• W2090415718 hasAuthorship W2090415718A5034905768 @default.
• W2090415718 hasAuthorship W2090415718A5034927209 @default.
• W2090415718 hasAuthorship W2090415718A5035774671 @default.
• W2090415718 hasAuthorship W2090415718A5073284191 @default.
• W2090415718 hasAuthorship W2090415718A5083494051 @default.
• W2090415718 hasBestOaLocation W20904157181 @default.
• W2090415718 hasConcept C121157162 @default.
• W2090415718 hasConcept C126322002 @default.
• W2090415718 hasConcept C136238340 @default.
• W2090415718 hasConcept C139447449 @default.
• W2090415718 hasConcept C142724271 @default.
• W2090415718 hasConcept C158617107 @default.
• W2090415718 hasConcept C185592680 @default.
• W2090415718 hasConcept C204328495 @default.
• W2090415718 hasConcept C2777633098 @default.
• W2090415718 hasConcept C2779134260 @default.
• W2090415718 hasConcept C2779491297 @default.
• W2090415718 hasConcept C2779951007 @default.
• W2090415718 hasConcept C2909607560 @default.
• W2090415718 hasConcept C29730261 @default.
• W2090415718 hasConcept C2994168385 @default.
• W2090415718 hasConcept C3019447875 @default.
• W2090415718 hasConcept C71924100 @default.

• next