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• W2090422762 abstract "To evaluate the safety and tolerability of high-dose formoterol and salbutamol in patients with chronic obstructive pulmonary disease (COPD).In this two-way crossover, double-blind, double-dummy study, 17 adults with mild-to-moderate COPD were randomized to receive either formoterol 24μg (2×12μg via Aerolizer®), or salbutamol 600μg (6×100μg via metered-dose inhaler), and the appropriate double-dummy q.i.d. at 4-h intervals for 3 consecutive days (total daily dose: 96 and 2400μg, respectively). After a 4–7-day washout period, patients were switched to the other treatment.Treatment with high-dose formoterol and salbutamol was equally well tolerated, with no reports of serious adverse events. Both agents were associated with decreased plasma potassium (mean minimum values: 3.4 and 3.3mmol/l for formoterol and salbutamol, respectively; P=0.914), increased serum glucose (mean maximum values: 9.0 and 8.7mmol/l, respectively; P=0.373), and small increases in mean QTc interval (mean maximum 439ms with both treatments; P=0.813). No clinically relevant between-treatment differences in adverse events or laboratory values occurred. Both drugs improved lung function (mean maximum forced expiratory volume in 1s [FEV1] 2.6l with both treatments; P=0.624), with the improvement being significantly greater with formoterol than with salbutamol on all 3 days of treatment (mean area under the curve [AUC](0–24h) of FEV1 formoterol vs. salbutamol on days 1–3, all P<0.05).High-dose formoterol via Aerolizer® (up to 96μg/day) has a comparable tolerability profile to that of salbutamol in patients with mild-to-moderate COPD." @default.
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• W2090422762 date "2006-04-01" @default.
• W2090422762 modified "2023-10-05" @default.
• W2090422762 title "Safety and tolerability of high-dose formoterol (via Aerolizer®) and salbutamol in patients with chronic obstructive pulmonary disease" @default.
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• W2090422762 doi "https://doi.org/10.1016/j.rmed.2005.07.017" @default.
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