FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090429237> ?p ?o ?g. }

• W2090429237 endingPage "1397" @default.
• W2090429237 startingPage "1391" @default.
• W2090429237 abstract "Background & Aims The pathogenesis of intestinal failure (IF) associated liver disease (IFALD) is uncertain, we therefore investigated the role of FGF19 and pro-inflammatory cytokines has on this disease state. Methods Serum FGF19, IL-6 and, TNF-α were measured in 52 IF patients at median age 6.0 years (IQR 2.2–13) after 10 months (4.1–39) on parenteral nutrition (PN). Thirty-nine patients underwent liver biopsies. Results In IF patients, FGF19 concentrations were lower and those of IL-6 and TNF-α higher compared to healthy matched controls (p ⩽0.001 for all). FGF19 concentrations were further decreased in patients without a remaining ileum [37 pg/ml (IQR 30–68) vs. 74 (35–135) p = 0.028], and correlated with remaining ileum length (r = 0.333, p = 0.018) and markers of cholesterol synthesis (r = −0.552 to −0.643, p <0.001). Patients with histological portal inflammation [30 pg/ml (28–45) vs. 48 (33–100), p = 0.019] or fibrosis [35 pg/ml (30–66) vs. 99 (38–163), p = 0.013] had lower serum FGF19 concentrations than others. FGF19 negatively correlated with portal inflammation grade (r = −0.442, p = 0.005), serum TNF-α (r = −0.318, p = 0.025), METAVIR fibrosis stage (r = −0.441, p = 0.005) and APRI (r = −0.328, p = 0.028). IL-6 was higher during PN [6 pg/ml (2–31)] than after weaning off PN [2 pg/ml (1–5), p = 0.009], correlated weakly with cholestasis grade (r = 0.328, p = 0.044), and tended to associate with histological cholestasis [n = 5, 5 pg/ml (5–267) vs. n = 34, 2 pg/ml (1–7), p = 0.058]. Conclusions In pediatric onset of IF, total or partial loss of ileum decreases serum FGF19 concentration corresponding to hepatic inflammation and fibrosis, along with increased cholesterol synthesis. In contrast, serum IL-6 increases during PN and may associate with concurrent cholestasis. These data suggests that FGF19 may contribute to the pathogenesis of IFALD. The pathogenesis of intestinal failure (IF) associated liver disease (IFALD) is uncertain, we therefore investigated the role of FGF19 and pro-inflammatory cytokines has on this disease state. Serum FGF19, IL-6 and, TNF-α were measured in 52 IF patients at median age 6.0 years (IQR 2.2–13) after 10 months (4.1–39) on parenteral nutrition (PN). Thirty-nine patients underwent liver biopsies. In IF patients, FGF19 concentrations were lower and those of IL-6 and TNF-α higher compared to healthy matched controls (p ⩽0.001 for all). FGF19 concentrations were further decreased in patients without a remaining ileum [37 pg/ml (IQR 30–68) vs. 74 (35–135) p = 0.028], and correlated with remaining ileum length (r = 0.333, p = 0.018) and markers of cholesterol synthesis (r = −0.552 to −0.643, p <0.001). Patients with histological portal inflammation [30 pg/ml (28–45) vs. 48 (33–100), p = 0.019] or fibrosis [35 pg/ml (30–66) vs. 99 (38–163), p = 0.013] had lower serum FGF19 concentrations than others. FGF19 negatively correlated with portal inflammation grade (r = −0.442, p = 0.005), serum TNF-α (r = −0.318, p = 0.025), METAVIR fibrosis stage (r = −0.441, p = 0.005) and APRI (r = −0.328, p = 0.028). IL-6 was higher during PN [6 pg/ml (2–31)] than after weaning off PN [2 pg/ml (1–5), p = 0.009], correlated weakly with cholestasis grade (r = 0.328, p = 0.044), and tended to associate with histological cholestasis [n = 5, 5 pg/ml (5–267) vs. n = 34, 2 pg/ml (1–7), p = 0.058]. In pediatric onset of IF, total or partial loss of ileum decreases serum FGF19 concentration corresponding to hepatic inflammation and fibrosis, along with increased cholesterol synthesis. In contrast, serum IL-6 increases during PN and may associate with concurrent cholestasis. These data suggests that FGF19 may contribute to the pathogenesis of IFALD." @default.
• W2090429237 created "2016-06-24" @default.
• W2090429237 creator A5012008888 @default.
• W2090429237 creator A5026588370 @default.
• W2090429237 creator A5031942948 @default.
• W2090429237 creator A5077865830 @default.
• W2090429237 creator A5083249645 @default.
• W2090429237 date "2015-06-01" @default.
• W2090429237 modified "2023-10-10" @default.
• W2090429237 title "Loss of ileum decreases serum fibroblast growth factor 19 in relation to liver inflammation and fibrosis in pediatric onset intestinal failure" @default.
• W2090429237 cites W1963917835 @default.
• W2090429237 cites W1966676383 @default.
• W2090429237 cites W1967066877 @default.
• W2090429237 cites W1972417331 @default.
• W2090429237 cites W1972544609 @default.
• W2090429237 cites W1974804865 @default.
• W2090429237 cites W1982099507 @default.
• W2090429237 cites W1985782544 @default.
• W2090429237 cites W1987649930 @default.
• W2090429237 cites W1997865776 @default.
• W2090429237 cites W1999889052 @default.
• W2090429237 cites W2002050129 @default.
• W2090429237 cites W2005895469 @default.
• W2090429237 cites W2015162068 @default.
• W2090429237 cites W2023902430 @default.
• W2090429237 cites W2027239974 @default.
• W2090429237 cites W2031358380 @default.
• W2090429237 cites W2040470970 @default.
• W2090429237 cites W2041451676 @default.
• W2090429237 cites W2046216502 @default.
• W2090429237 cites W2048453651 @default.
• W2090429237 cites W2052439286 @default.
• W2090429237 cites W2052527505 @default.
• W2090429237 cites W2061365952 @default.
• W2090429237 cites W2072993881 @default.
• W2090429237 cites W2082162513 @default.
• W2090429237 cites W2084198575 @default.
• W2090429237 cites W2091343301 @default.
• W2090429237 cites W2094174828 @default.
• W2090429237 cites W2114432301 @default.
• W2090429237 cites W2116533117 @default.
• W2090429237 cites W2117616183 @default.
• W2090429237 cites W2126949934 @default.
• W2090429237 cites W2130220620 @default.
• W2090429237 cites W2143605781 @default.
• W2090429237 cites W2145693804 @default.
• W2090429237 cites W2146012023 @default.
• W2090429237 cites W2150113459 @default.
• W2090429237 cites W2151965006 @default.
• W2090429237 cites W2152035679 @default.
• W2090429237 cites W2153677691 @default.
• W2090429237 cites W2157122212 @default.
• W2090429237 cites W2162888435 @default.
• W2090429237 cites W2166976145 @default.
• W2090429237 cites W2168230582 @default.
• W2090429237 cites W2168741168 @default.
• W2090429237 doi "https://doi.org/10.1016/j.jhep.2015.01.004" @default.
• W2090429237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25595885" @default.
• W2090429237 hasPublicationYear "2015" @default.
• W2090429237 type Work @default.
• W2090429237 sameAs 2090429237 @default.
• W2090429237 citedByCount "63" @default.
• W2090429237 countsByYear W20904292372015 @default.
• W2090429237 countsByYear W20904292372016 @default.
• W2090429237 countsByYear W20904292372017 @default.
• W2090429237 countsByYear W20904292372018 @default.
• W2090429237 countsByYear W20904292372019 @default.
• W2090429237 countsByYear W20904292372020 @default.
• W2090429237 countsByYear W20904292372021 @default.
• W2090429237 countsByYear W20904292372022 @default.
• W2090429237 countsByYear W20904292372023 @default.
• W2090429237 crossrefType "journal-article" @default.
• W2090429237 hasAuthorship W2090429237A5012008888 @default.
• W2090429237 hasAuthorship W2090429237A5026588370 @default.
• W2090429237 hasAuthorship W2090429237A5031942948 @default.
• W2090429237 hasAuthorship W2090429237A5077865830 @default.
• W2090429237 hasAuthorship W2090429237A5083249645 @default.
• W2090429237 hasConcept C126322002 @default.
• W2090429237 hasConcept C134018914 @default.
• W2090429237 hasConcept C170493617 @default.
• W2090429237 hasConcept C2775936931 @default.
• W2090429237 hasConcept C2776914184 @default.
• W2090429237 hasConcept C2777075537 @default.
• W2090429237 hasConcept C2777226302 @default.
• W2090429237 hasConcept C2778593092 @default.
• W2090429237 hasConcept C2780559512 @default.
• W2090429237 hasConcept C2780655333 @default.
• W2090429237 hasConcept C2780942790 @default.
• W2090429237 hasConcept C71924100 @default.
• W2090429237 hasConcept C74373430 @default.
• W2090429237 hasConcept C90924648 @default.
• W2090429237 hasConceptScore W2090429237C126322002 @default.
• W2090429237 hasConceptScore W2090429237C134018914 @default.
• W2090429237 hasConceptScore W2090429237C170493617 @default.
• W2090429237 hasConceptScore W2090429237C2775936931 @default.
• W2090429237 hasConceptScore W2090429237C2776914184 @default.
• W2090429237 hasConceptScore W2090429237C2777075537 @default.
• W2090429237 hasConceptScore W2090429237C2777226302 @default.

• next