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- W2090439577 abstract "Selective alkylation of dyphylline (1) with (2-acetoxyethoxy)methyl bromide (2a) or 4-acetoxybutyl bromide (2b) afforded 3'-O-[(acetoxyethoxy)methyl]dyphylline (3a) and 3'-O-(4-acetoxybutyl)-dyphylline (3b), respectively. A trans esterification process rather than alkylation of the dihydroxy-propyl side chain in 1 had taken place during the reaction with 2-p-toluoyloxy)ethyl chloride (5) to afford the respective 3'-toluoyloxy derivative 7 and not the anticipated 3'-O-[(p-toluoyloxy)ethyl]-dyphylline (6). Deacylation of 3a,b and 7 afforded 4a,b and 1, respectively. Viral screening of selected compounds against HBV has been investigated." @default.
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- W2090439577 date "2008-02-08" @default.
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- W2090439577 title "Synthesis and Activity Against HBV of Novel <i>Tetra-</i>Seconucleoside Analogues of Dyphlline Having the Acyclic Chains of ACV and HBG" @default.
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- W2090439577 doi "https://doi.org/10.1080/15257770701845329" @default.
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