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- W2090445148 abstract "Abstract THE HIGH-molecular weight polysaccharide, hyaluronic acid (HA), originally thought to serve only as a structural function in loose connective tissue, has now been found to play important roles in such diverse biological processes as cell adhesion1−3 and mobility, tissue morphogenesis, and in several inflammatory diseases. The properties of HA are important in water homeostasis of the tissues, as HA is an ubiquitous molecule in the interstitium, with unique water-binding qualities, attracting water by osmotic forces and resisting water flow.4 Assuming that HA synthesis is enhanced during rejection or inflammation, excessive accumulation of the acid in interstitial tissue might immobilize water and thereby contribute to the development of graft edema. This has been described in rat renal transplants,5 and in rat heart6 and small bowel allografts.7,8 In this study, we quantified HA in the intestinal mucosa of the donor before and after transplantation, with the aim of correlating the HA content to different grade of damage in a grafted small bowel; histologic aspects of the examined samples were also taken into account." @default.
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- W2090445148 date "1997-05-01" @default.
- W2090445148 modified "2023-10-16" @default.
- W2090445148 title "Intestinal damage evaluation in swine allograft small bowel through hyaluronic acid quantification" @default.
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- W2090445148 doi "https://doi.org/10.1016/s0041-1345(97)00089-4" @default.
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