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- W2090455003 abstract "A bioassay-guided fractionation of the 70% acetone extract of the bark of Guazuma ulmifolia Lam. on the inhibition of angiotensin II binding to the AT 1 receptor led to the isolation and identification of bioactive oligomeric and polymeric proanthocyanidins consisting mainly of (-)-epicatechin units. The displacement of [3H]-angiotensin II binding was dose-dependent and correlated with the degree of polymerization of the different fractions containing proanthocyanidins. A strong displacement was seen for the residual fraction suggesting that the most active substances corresponding to the highly polymerized proanthocyanidins. Angiotensin II AT 1 receptor binding might be considered as a potentially interesting biological activity of proanthocyanidins contributing to the very broad spectrum of biological activities of the condensed tannins." @default.
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- W2090455003 date "2002-12-01" @default.
- W2090455003 modified "2023-10-16" @default.
- W2090455003 title "<i>In Vitro</i>Inhibition of [<sup>3</sup> <i>H</i>]-Angiotensin II Binding on the Human AT<sub>1</sub>Receptor by Proanthocyanidins from<i>Guazuma ulmifolia</i>Bark" @default.
- W2090455003 doi "https://doi.org/10.1055/s-2002-36344" @default.
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