FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090467716> ?p ?o ?g. }

• W2090467716 endingPage "1056" @default.
• W2090467716 startingPage "1042" @default.
• W2090467716 abstract "HNF-1 alpha (previously referred to as HNF-1, LPB1, and APF) is a vertebrate transcription factor that contains a divergent homeo domain and plays a prominent role in regulating genes that have the common characteristic of being expressed in hepatocytes and a complex group of endodermally and mesodermally derived tissues. HNF-1 alpha is unique among the vertebrate homeo domain-containing proteins in that it dimerizes in the absence of its DNA recognition sequence, suggesting the possibility that the function of HNF-1 alpha may be diversified by forming heterodimers with other related proteins. We report the initial characterization of HNF-1 beta, which is closely related to HNF-1 alpha and is able to form heterodimers with HNF-1 alpha in vitro. Although HNF-1 alpha, but not HNF-1 beta, is expressed in the liver, HNF-1 alpha and HNF-1 beta are coexpressed in the murine Hepa1A cell line and in the mammalian kidney where a subset of hepatocyte genes are expressed. In contrast, exclusive expression of HNF-1 beta is associated with repression of a subset of hepatocyte-specific genes in the dedifferentiated hepatocyte cell line C2, differentiated F9 cells, in somatic hybrids between hepatocytes and fibroblasts, and in the lung. The extent of heterodimerization may be regulated in a tissue-specific way because freely exchangeable heterodimers are formed in Jurkat T cells transfected with HNF-1 alpha and HNF-1 beta, whereas in liver cells stable homodimers are present. These studies define a pair of homeo domain proteins that have the potential to interact to produce an embryologically complex pattern of gene expression." @default.
• W2090467716 created "2016-06-24" @default.
• W2090467716 creator A5043804904 @default.
• W2090467716 creator A5054604221 @default.
• W2090467716 creator A5060596240 @default.
• W2090467716 creator A5061089703 @default.
• W2090467716 creator A5082977812 @default.
• W2090467716 date "1991-06-01" @default.
• W2090467716 modified "2023-10-01" @default.
• W2090467716 title "HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro." @default.
• W2090467716 cites W1501868120 @default.
• W2090467716 cites W1570288165 @default.
• W2090467716 cites W1768247331 @default.
• W2090467716 cites W1922068407 @default.
• W2090467716 cites W1969809090 @default.
• W2090467716 cites W1974217132 @default.
• W2090467716 cites W1975045802 @default.
• W2090467716 cites W1978819530 @default.
• W2090467716 cites W1979551779 @default.
• W2090467716 cites W1981286265 @default.
• W2090467716 cites W1982910659 @default.
• W2090467716 cites W1984751884 @default.
• W2090467716 cites W1989054182 @default.
• W2090467716 cites W1996131391 @default.
• W2090467716 cites W2004563262 @default.
• W2090467716 cites W2004626037 @default.
• W2090467716 cites W2005393972 @default.
• W2090467716 cites W2013607556 @default.
• W2090467716 cites W201453924 @default.
• W2090467716 cites W2020944732 @default.
• W2090467716 cites W2022214933 @default.
• W2090467716 cites W2030904938 @default.
• W2090467716 cites W2033302775 @default.
• W2090467716 cites W2034454625 @default.
• W2090467716 cites W2034994122 @default.
• W2090467716 cites W2036553614 @default.
• W2090467716 cites W2047203795 @default.
• W2090467716 cites W2049672602 @default.
• W2090467716 cites W2055257235 @default.
• W2090467716 cites W2058744360 @default.
• W2090467716 cites W2059556539 @default.
• W2090467716 cites W2062423659 @default.
• W2090467716 cites W2065553730 @default.
• W2090467716 cites W2066215499 @default.
• W2090467716 cites W2068398119 @default.
• W2090467716 cites W2073403442 @default.
• W2090467716 cites W2075193060 @default.
• W2090467716 cites W2080132636 @default.
• W2090467716 cites W2082670705 @default.
• W2090467716 cites W2086950550 @default.
• W2090467716 cites W2091626902 @default.
• W2090467716 cites W2091879363 @default.
• W2090467716 cites W2117969708 @default.
• W2090467716 cites W2119577005 @default.
• W2090467716 cites W2123903336 @default.
• W2090467716 cites W2126093778 @default.
• W2090467716 cites W2154128645 @default.
• W2090467716 cites W2159511823 @default.
• W2090467716 cites W2265338784 @default.
• W2090467716 cites W249314811 @default.
• W2090467716 cites W4293247451 @default.
• W2090467716 cites W55452206 @default.
• W2090467716 doi "https://doi.org/10.1101/gad.5.6.1042" @default.
• W2090467716 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2044952" @default.
• W2090467716 hasPublicationYear "1991" @default.
• W2090467716 type Work @default.
• W2090467716 sameAs 2090467716 @default.
• W2090467716 citedByCount "299" @default.
• W2090467716 countsByYear W20904677162012 @default.
• W2090467716 countsByYear W20904677162013 @default.
• W2090467716 countsByYear W20904677162014 @default.
• W2090467716 countsByYear W20904677162015 @default.
• W2090467716 countsByYear W20904677162016 @default.
• W2090467716 countsByYear W20904677162017 @default.
• W2090467716 countsByYear W20904677162018 @default.
• W2090467716 countsByYear W20904677162019 @default.
• W2090467716 countsByYear W20904677162020 @default.
• W2090467716 countsByYear W20904677162021 @default.
• W2090467716 countsByYear W20904677162022 @default.
• W2090467716 countsByYear W20904677162023 @default.
• W2090467716 crossrefType "journal-article" @default.
• W2090467716 hasAuthorship W2090467716A5043804904 @default.
• W2090467716 hasAuthorship W2090467716A5054604221 @default.
• W2090467716 hasAuthorship W2090467716A5060596240 @default.
• W2090467716 hasAuthorship W2090467716A5061089703 @default.
• W2090467716 hasAuthorship W2090467716A5082977812 @default.
• W2090467716 hasBestOaLocation W20904677161 @default.
• W2090467716 hasConcept C104317684 @default.
• W2090467716 hasConcept C153911025 @default.
• W2090467716 hasConcept C202751555 @default.
• W2090467716 hasConcept C2776200302 @default.
• W2090467716 hasConcept C54009773 @default.
• W2090467716 hasConcept C54355233 @default.
• W2090467716 hasConcept C63932345 @default.
• W2090467716 hasConcept C72699923 @default.
• W2090467716 hasConcept C86339819 @default.
• W2090467716 hasConcept C86803240 @default.
• W2090467716 hasConcept C95444343 @default.

• next