Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090479804> ?p ?o ?g. }
- W2090479804 endingPage "177" @default.
- W2090479804 startingPage "169" @default.
- W2090479804 abstract "Intermittent treatment with human parathyroid hormone (1-34) [hPTH(1-34)] stimulates bone formation and increases cancellous bone mass in ovariectomized (OVX) rats. But PTH-induced cancellous bone rapidly disappears upon cessation of treatment. The fate of cortical bone treated by PTH has not been well characterized. Incadronate disodium (disodium cycloheptylaminomethylenedisphosphonate monohydrate, YM175) was expected to be antiresorptive without inhibiting bone formation. The purposes of this study were to determine (1) whether PTH treatment increases new cancellous and cortical bone mass and bone formation, (2) whether the new bone could be maintained by YM175 sequential treatment, and (3) whether the maintenance effect is persistent after YM175 withdrawal. Eighty-eight 11-week-old Sprague-Dawley rats were divided into sham operation and OVX groups. The OVX rats were treated for 8 weeks with the subcutaneous intermittent injection of 30 micrograms/kg of hPTH(1-34) three times a week beginning 4 weeks after surgery, then PTH treatment was withdrawn and YM175 (10 micrograms/kg) was injected subcutaneously three times a week for 4 weeks. YM175 treatment was withdrawn for the last 8 weeks of the protocol. The results of microstructural assessment in proximal tibial metaphysis and bone mineral density in distal and proximal femur demonstrated that PTH treatment for 8 weeks restored bone mass to the sham control level. However, after cessation of PTH treatment, the PTH-induced tibial cancellous bone mass showed a decrease at 4 weeks and almost totally disappeared after 12 weeks. Conversely, YM175 treatment maintained the PTH-induced tibial cancellous bone mass, and the bone continued to be maintained after 8 weeks of withdrawal of the YM175. Cortical bone was not lost during PTH treatment. YM175 maintained the PTH-induced new tibial cancellous bone in OVX rats by suppressing remodeling." @default.
- W2090479804 created "2016-06-24" @default.
- W2090479804 creator A5031581472 @default.
- W2090479804 creator A5054276880 @default.
- W2090479804 creator A5061421299 @default.
- W2090479804 creator A5068272592 @default.
- W2090479804 creator A5068462140 @default.
- W2090479804 creator A5086153559 @default.
- W2090479804 date "2009-12-03" @default.
- W2090479804 modified "2023-10-16" @default.
- W2090479804 title "Maintaining bone mass by bisphosphonate incadronate disodium (YM175) sequential treatment after discontinuation of intermittent human parathyroid hormone (1-34) administration in ovariectomized rats" @default.
- W2090479804 cites W1967253907 @default.
- W2090479804 cites W1968814931 @default.
- W2090479804 cites W1970995146 @default.
- W2090479804 cites W1972828099 @default.
- W2090479804 cites W1973715637 @default.
- W2090479804 cites W1979471317 @default.
- W2090479804 cites W1981052327 @default.
- W2090479804 cites W1986841828 @default.
- W2090479804 cites W1994322925 @default.
- W2090479804 cites W1996164381 @default.
- W2090479804 cites W1997617266 @default.
- W2090479804 cites W2001055663 @default.
- W2090479804 cites W2002158790 @default.
- W2090479804 cites W2005843802 @default.
- W2090479804 cites W2007569697 @default.
- W2090479804 cites W2015287543 @default.
- W2090479804 cites W2015576315 @default.
- W2090479804 cites W2025143421 @default.
- W2090479804 cites W2027589450 @default.
- W2090479804 cites W2028655010 @default.
- W2090479804 cites W2031148025 @default.
- W2090479804 cites W2044010302 @default.
- W2090479804 cites W2047312094 @default.
- W2090479804 cites W2047644681 @default.
- W2090479804 cites W2056878844 @default.
- W2090479804 cites W2061181564 @default.
- W2090479804 cites W2061593831 @default.
- W2090479804 cites W2062513753 @default.
- W2090479804 cites W2064390254 @default.
- W2090479804 cites W2076529427 @default.
- W2090479804 cites W2078746923 @default.
- W2090479804 cites W2079810909 @default.
- W2090479804 cites W2079933145 @default.
- W2090479804 cites W2080885494 @default.
- W2090479804 cites W2088640839 @default.
- W2090479804 cites W2092701996 @default.
- W2090479804 cites W2116921062 @default.
- W2090479804 cites W2123889083 @default.
- W2090479804 cites W2132973962 @default.
- W2090479804 cites W2237740661 @default.
- W2090479804 cites W2290774861 @default.
- W2090479804 doi "https://doi.org/10.1002/jbmr.5650110205" @default.
- W2090479804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8822340" @default.
- W2090479804 hasPublicationYear "2009" @default.
- W2090479804 type Work @default.
- W2090479804 sameAs 2090479804 @default.
- W2090479804 citedByCount "38" @default.
- W2090479804 countsByYear W20904798042014 @default.
- W2090479804 countsByYear W20904798042015 @default.
- W2090479804 countsByYear W20904798042016 @default.
- W2090479804 countsByYear W20904798042018 @default.
- W2090479804 countsByYear W20904798042019 @default.
- W2090479804 countsByYear W20904798042022 @default.
- W2090479804 crossrefType "journal-article" @default.
- W2090479804 hasAuthorship W2090479804A5031581472 @default.
- W2090479804 hasAuthorship W2090479804A5054276880 @default.
- W2090479804 hasAuthorship W2090479804A5061421299 @default.
- W2090479804 hasAuthorship W2090479804A5068272592 @default.
- W2090479804 hasAuthorship W2090479804A5068462140 @default.
- W2090479804 hasAuthorship W2090479804A5086153559 @default.
- W2090479804 hasConcept C105702510 @default.
- W2090479804 hasConcept C126322002 @default.
- W2090479804 hasConcept C134018914 @default.
- W2090479804 hasConcept C141071460 @default.
- W2090479804 hasConcept C2776350087 @default.
- W2090479804 hasConcept C2776541429 @default.
- W2090479804 hasConcept C2776886416 @default.
- W2090479804 hasConcept C2777164284 @default.
- W2090479804 hasConcept C2781208988 @default.
- W2090479804 hasConcept C2781451080 @default.
- W2090479804 hasConcept C519063684 @default.
- W2090479804 hasConcept C71924100 @default.
- W2090479804 hasConcept C8264082 @default.
- W2090479804 hasConceptScore W2090479804C105702510 @default.
- W2090479804 hasConceptScore W2090479804C126322002 @default.
- W2090479804 hasConceptScore W2090479804C134018914 @default.
- W2090479804 hasConceptScore W2090479804C141071460 @default.
- W2090479804 hasConceptScore W2090479804C2776350087 @default.
- W2090479804 hasConceptScore W2090479804C2776541429 @default.
- W2090479804 hasConceptScore W2090479804C2776886416 @default.
- W2090479804 hasConceptScore W2090479804C2777164284 @default.
- W2090479804 hasConceptScore W2090479804C2781208988 @default.
- W2090479804 hasConceptScore W2090479804C2781451080 @default.
- W2090479804 hasConceptScore W2090479804C519063684 @default.
- W2090479804 hasConceptScore W2090479804C71924100 @default.
- W2090479804 hasConceptScore W2090479804C8264082 @default.
- W2090479804 hasIssue "2" @default.