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- W2090485310 abstract "Primary biliary cirrhosis (PBC) is a chronic autoimmune liver disease characterized by inflammation and destruction of intrahepatic biliary epithelial cells, ultimately leading to liver failure. The serological hallmark of PBC is the presence of high-titer antimitochondrial antibodies (AMA) against the inner lipoyl domain of E2 subunits of 2-oxo-acid dehydrogenase complexes, in particular the E2 component of the pyruvate dehydrogenase complex (PDC-E2). The initiating events triggering the autoimmune response are not yet identified but the hypothesis of molecular mimicry is a widely proposed mechanism for the development of autoimmunity in PBC. Several candidates, including bacteria and viruses, have been suggested as causative agents, but also environmental factors, such as chemical xenobiotics, have been implicated in the pathogenesis of primary biliary cirrhosis. In this review, we will discuss our current knowledge of the immunoreactivity of xenobiotically modified PDC peptide antigens. In addition, we will provide a working hypothesis how xenobiotic modification of antigens might occur that ultimately leads to the breaking of self-tolerance and the induction of PBC." @default.
- W2090485310 created "2016-06-24" @default.
- W2090485310 creator A5029678899 @default.
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- W2090485310 date "2007-03-01" @default.
- W2090485310 modified "2023-09-30" @default.
- W2090485310 title "The X and why of xenobiotics in primary biliary cirrhosis" @default.
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- W2090485310 cites W1494611508 @default.
- W2090485310 cites W159986264 @default.
- W2090485310 cites W1650215555 @default.
- W2090485310 cites W1936555387 @default.
- W2090485310 cites W1956131600 @default.
- W2090485310 cites W1965719800 @default.
- W2090485310 cites W1965727970 @default.
- W2090485310 cites W1971455565 @default.
- W2090485310 cites W1971693959 @default.
- W2090485310 cites W1977492688 @default.
- W2090485310 cites W1981803844 @default.
- W2090485310 cites W1990204841 @default.
- W2090485310 cites W1998722289 @default.
- W2090485310 cites W1999620400 @default.
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- W2090485310 cites W2007870105 @default.
- W2090485310 cites W2009606660 @default.
- W2090485310 cites W2018027744 @default.
- W2090485310 cites W2018800904 @default.
- W2090485310 cites W2019416317 @default.
- W2090485310 cites W202401836 @default.
- W2090485310 cites W2026711162 @default.
- W2090485310 cites W2030083654 @default.
- W2090485310 cites W2031658333 @default.
- W2090485310 cites W2032540254 @default.
- W2090485310 cites W2034210831 @default.
- W2090485310 cites W2038433722 @default.
- W2090485310 cites W2039583607 @default.
- W2090485310 cites W2040375465 @default.
- W2090485310 cites W2041440910 @default.
- W2090485310 cites W2042145118 @default.
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- W2090485310 doi "https://doi.org/10.1016/j.jaut.2007.02.003" @default.
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