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• W2090486087 abstract "New solid-phase strategies have been developed for the synthesis of lidocaine (1) and procainamide (2) analogues, using backbone amide linker (BAL) anchoring. Both sets were prepared starting from a common resin-bound intermediate, followed by four general steps: (i) attachment of a primary aliphatic or aromatic amine to the solid support via reductive amination (as monitored by a novel test involving reaction of 2,4-dinitrophenylhydrazine with residual aldehyde groups); (ii) acylation of the resultant secondary amine; (iii) displacement of halide with an amine; and (iv) trifluoroacetic acid-mediated release from the support. A manual parallel strategy was followed to provide 60 novel compounds, of which two dozen have not been previously described. In most cases, initial crude purities were >80%, and overall isolated yields were in the 40-88% range." @default.
• W2090486087 created "2016-06-24" @default.
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• W2090486087 date "2003-10-25" @default.
• W2090486087 modified "2023-10-17" @default.
• W2090486087 title "Solid-Phase Synthesis of Lidocaine and Procainamide Analogues Using Backbone Amide Linker (BAL) Anchoring" @default.
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• W2090486087 doi "https://doi.org/10.1021/cc034014n" @default.
• W2090486087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14606816" @default.
• W2090486087 hasPublicationYear "2003" @default.
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