Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090495875> ?p ?o ?g. }
- W2090495875 endingPage "231" @default.
- W2090495875 startingPage "225" @default.
- W2090495875 abstract "The nucleoside analog 2-chlorodeoxyadenosine (CdA, Cladribine) is a chemotherapeutic agent for treatment of leukemias and lymphomas, most successfully used in hairy cell leukemia and B-cell chronic lymphocytic leukemia. CdA is phosphorylated intracellularly to its monophosphate derivative by the enzymes deoxycytidine kinase and deoxyguanosine kinase. Cell lines deficient in deoxycytidine kinase were shown to be resistant to CdA and a high deoxycytidine kinase level in combination with low 5'-nucleotidase has been proposed to partly explain the selectivity in CdA toxicity for lymphoid cells. In this report biochemical properties in CdA phosphorylation mediated by deoxycytidine kinase and deoxyguanosine kinase are reviewed and discussed in relation to the further metabolism of CdA 5'-monophosphate, the different possible mechanisms of action and the correlation with clinical response. It is concluded that much is known about the metabolism and mechanisms of action of CdA, but that the remarkable therapeutic effect in hairy cell leukemia has yet to be explicitly explained." @default.
- W2090495875 created "2016-06-24" @default.
- W2090495875 creator A5012576392 @default.
- W2090495875 date "1996-01-01" @default.
- W2090495875 modified "2023-10-13" @default.
- W2090495875 title "On the Phosphorylation of 2-chlorodeoxy-adenosine (CdA) and Its Correlation with Clinical Response in Leukemia Treatment" @default.
- W2090495875 cites W121485390 @default.
- W2090495875 cites W1511106986 @default.
- W2090495875 cites W1511322026 @default.
- W2090495875 cites W1517287214 @default.
- W2090495875 cites W1533006219 @default.
- W2090495875 cites W1565947507 @default.
- W2090495875 cites W159981870 @default.
- W2090495875 cites W1968152365 @default.
- W2090495875 cites W1973470645 @default.
- W2090495875 cites W1980075357 @default.
- W2090495875 cites W1981859457 @default.
- W2090495875 cites W1986918122 @default.
- W2090495875 cites W1991112301 @default.
- W2090495875 cites W1999516176 @default.
- W2090495875 cites W2006456486 @default.
- W2090495875 cites W2008734787 @default.
- W2090495875 cites W2011480489 @default.
- W2090495875 cites W2011960809 @default.
- W2090495875 cites W2017505748 @default.
- W2090495875 cites W2020062312 @default.
- W2090495875 cites W2027719195 @default.
- W2090495875 cites W2028969708 @default.
- W2090495875 cites W2031890808 @default.
- W2090495875 cites W2037690793 @default.
- W2090495875 cites W2044041384 @default.
- W2090495875 cites W2046370286 @default.
- W2090495875 cites W2048245819 @default.
- W2090495875 cites W2048415378 @default.
- W2090495875 cites W2054701700 @default.
- W2090495875 cites W2056226887 @default.
- W2090495875 cites W2056414768 @default.
- W2090495875 cites W2057941278 @default.
- W2090495875 cites W2063187218 @default.
- W2090495875 cites W2074677735 @default.
- W2090495875 cites W2074880157 @default.
- W2090495875 cites W2075225888 @default.
- W2090495875 cites W2076316345 @default.
- W2090495875 cites W2079752228 @default.
- W2090495875 cites W2082519456 @default.
- W2090495875 cites W2085223838 @default.
- W2090495875 cites W2086984633 @default.
- W2090495875 cites W2091011875 @default.
- W2090495875 cites W2093943927 @default.
- W2090495875 cites W2114274933 @default.
- W2090495875 cites W2132135186 @default.
- W2090495875 cites W2145370011 @default.
- W2090495875 cites W218420279 @default.
- W2090495875 cites W2314659489 @default.
- W2090495875 cites W2335263466 @default.
- W2090495875 cites W4233161682 @default.
- W2090495875 cites W4240037281 @default.
- W2090495875 cites W4249933453 @default.
- W2090495875 cites W92105219 @default.
- W2090495875 doi "https://doi.org/10.3109/10428199209067604" @default.
- W2090495875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8726403" @default.
- W2090495875 hasPublicationYear "1996" @default.
- W2090495875 type Work @default.
- W2090495875 sameAs 2090495875 @default.
- W2090495875 citedByCount "33" @default.
- W2090495875 countsByYear W20904958752014 @default.
- W2090495875 countsByYear W20904958752016 @default.
- W2090495875 countsByYear W20904958752019 @default.
- W2090495875 countsByYear W20904958752020 @default.
- W2090495875 countsByYear W20904958752022 @default.
- W2090495875 crossrefType "journal-article" @default.
- W2090495875 hasAuthorship W2090495875A5012576392 @default.
- W2090495875 hasConcept C121608353 @default.
- W2090495875 hasConcept C184235292 @default.
- W2090495875 hasConcept C185592680 @default.
- W2090495875 hasConcept C203014093 @default.
- W2090495875 hasConcept C2776543447 @default.
- W2090495875 hasConcept C2776991684 @default.
- W2090495875 hasConcept C2777844706 @default.
- W2090495875 hasConcept C2777938653 @default.
- W2090495875 hasConcept C2778461978 @default.
- W2090495875 hasConcept C2779200787 @default.
- W2090495875 hasConcept C2779268695 @default.
- W2090495875 hasConcept C2780258809 @default.
- W2090495875 hasConcept C2780441211 @default.
- W2090495875 hasConcept C2780483514 @default.
- W2090495875 hasConcept C2780636463 @default.
- W2090495875 hasConcept C502942594 @default.
- W2090495875 hasConcept C54355233 @default.
- W2090495875 hasConcept C552990157 @default.
- W2090495875 hasConcept C55493867 @default.
- W2090495875 hasConcept C86803240 @default.
- W2090495875 hasConceptScore W2090495875C121608353 @default.
- W2090495875 hasConceptScore W2090495875C184235292 @default.
- W2090495875 hasConceptScore W2090495875C185592680 @default.
- W2090495875 hasConceptScore W2090495875C203014093 @default.
- W2090495875 hasConceptScore W2090495875C2776543447 @default.
- W2090495875 hasConceptScore W2090495875C2776991684 @default.