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• W2090499400 abstract "<i>Background/Aims:</i> Fasting plasma glucose (FPG) levels correlate with cardiovascular disease and mortality in both diabetic and non-diabetic subjects. <i>G6PC2</i> encodes a pancreatic islet-specific glucose-6-phosphatase-related protein and <i>G6pc2</i>-null mice were reported to exhibit decreased blood glucose levels. Two recent genome-wide association studies have implicated a role for <i>G6PC2</i> in regulation of FPGlevels in the general European population and reported the strongest association with the rs560887 SNP. The purpose of this study was to replicate this association in our independent epidemiological samples. <i>Methods:</i> DNA samples from non-Hispanic white Americans (NHWs; n = 623), Hispanic Americans (n = 410) and black Africans (n = 787) were genotyped for rs560887 using TaqMan allelic discrimination. <i>Results:</i> While no minor allele A of rs560887 was observed among blacks, its frequency was 33% in NHWs and 17.5% in Hispanics. The rs560887 minor allele was associated with reduced FPG levels in non-diabetic NHWs (p = 0.002 under an additive model). A similar trend of association was observed in non-diabetic Hispanics (p = 0.076 under a dominant model), which was more pronounced in normoglycemic subjects (p = 0.036). <i>Conclusions:</i> Our results independently confirm the robust association of G6PC2/rs560887 with FPG levels in non-diabetic NHWs. The observed evidence for association in Hispanics warrants further studies in larger samples." @default.
• W2090499400 created "2016-06-24" @default.
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• W2090499400 date "2009-12-18" @default.
• W2090499400 modified "2023-09-27" @default.
• W2090499400 title "Association of a Common G6PC2 Variant with Fasting Plasma Glucose Levels in Non-Diabetic Individuals" @default.
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• W2090499400 doi "https://doi.org/10.1159/000268019" @default.
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