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- W2090504184 abstract "Thyroid hormone receptor β (TRβ) dysfunction leads to deafness in humans and mice. Deafness in TRβ −/− mutant mice has been attributed to TRβ-mediated control of voltage- and Ca 2+ -activated K + (BK) channel expression in inner hair cells (IHCs). However, normal hearing in young constitutive BKα −/− mutants contradicts this hypothesis. Here, we show that mice with hair cell-specific deletion of TRβ after postnatal day 11 (P11) have a delay in BKα expression but normal hearing, indicating that the origin of hearing loss in TRβ −/− mutant mice manifested before P11. Analyzing the phenotype of IHCs in constitutive TRβ −/− mice, we found normal Ca 2+ current amplitudes, exocytosis, and shape of compound action potential waveforms. In contrast, reduced distortion product otoacoustic emissions and cochlear microphonics associated with an abnormal structure of the tectorial membrane and enhanced tectorin levels suggest that disturbed mechanical performance is the primary cause of deafness resulting from TRβ deficiency." @default.
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- W2090504184 date "2009-02-25" @default.
- W2090504184 modified "2023-09-26" @default.
- W2090504184 title "Deafness in TRβ Mutants Is Caused by Malformation of the Tectorial Membrane" @default.
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- W2090504184 doi "https://doi.org/10.1523/jneurosci.3557-08.2009" @default.
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