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- W2090506776 abstract "We examined the response of the α and β-cells of the perfused rat pancreas to an elevation of potassium ion concentration and to the potassium ionophore, valinomycin (1 × 10-6< M). Elevation of potassium from a baseline concentration of 5.8 mM to 11.3, 18.3, and 53.3 mM caused a biphasic release of immunoreactive insulin characterized by a spiked first phase and a low sustained second phase and a spiked release of immunoreactive glucagon followed by a very low sustained secretion that ended with the termination of the stimulation. The second phase of potassium-stimulated insulin release increased in the presence of basal glucose (3.3 mM). Sequential higher concentrations of potassium caused a dose-response increase in both phases of insulin release, but did not increase glucagon secretion. Valinomycin inhibited the insulin secretion caused by potassium, arginine, and glucose and the glucagon secretion caused by potassium and arginine. Potassium, when applied on the second phase of arginine-stimulated insu..." @default.
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- W2090506776 title "The Effect of Potassium and Valinomycin on Insulin and Grlucagon Secretion in the Perfused Rat Pancreas*" @default.
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- W2090506776 doi "https://doi.org/10.1210/endo-103-6-2207" @default.
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