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- W2090519989 abstract "The safety and tolerability of transferring maintained renal transplant patients from Sandimmun to Neoral is being assessed in a multicentre, open-label, single-arm study. A total of 250 patients has been enrolled and results are available from 75 patients up to 12 months post-transfer. A slight trend to higher mean cyclosporin trough levels was seen in this cohort, but trough levels were unchanged in the sub-group receiving > or = 1 dose changes. The mean dose fell by 13%. Creatinine levels showed a slight overall upward trend. Blood pressure and uric acid were unchanged and adverse events were typical of those seen with Sandimmun. Neoral was well-tolerated. Data from the full cohort of 250 patients up to 3 months post-transfer support these findings. These results indicate that transfer from Sandimmun to Neoral is safe and well-tolerated and provides appropriate immunosuppression at a lower average dose than Sandimmun. The Neoral dose should be adjusted promptly, as required, to maintain the target trough level." @default.
- W2090519989 created "2016-06-24" @default.
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- W2090519989 date "1996-01-01" @default.
- W2090519989 modified "2023-09-25" @default.
- W2090519989 title "UK multicentre study to assess the safety and tolerability of Neoral in stable renal transplant patients" @default.
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- W2090519989 doi "https://doi.org/10.1007/978-3-662-00818-8_77" @default.
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