FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090521110> ?p ?o ?g. }

• W2090521110 endingPage "453" @default.
• W2090521110 startingPage "447" @default.
• W2090521110 abstract "The IL-6-dependent activation of the JAK/STAT pathway plays a central role in the induction of the acute phase response in the liver. In a search for new inhibitors of the IL-6-mediated signal transduction in HepG2 cells using secreted alkaline phosphatase (SEAP) as reporter gene, four novel cyclopentenones, 2-(1-chloropropenyl)-4,5-dihydroxycyclopent-2-enone (CPDHC, 1), 4, 5-dihydroxy-2-propenylcyclopent-2-enone (DHPC, 2), 5-hydroxy-2, 3-dimethylcyclopent-2-enone (HDC, 3), and 4-methyl-5-methylenecyclopent-3-en-1,2-diol (MMCD, 4) were isolated from fermentations of the ascomycete strain A23-98. CPDHC (1) inhibits the IL-6-induced SEAP expression with IC(50) values of 4. 0-5.3 microM (0.75-1 microg/ml). The compounds DHPC (2), HDC (3), and MMCD (4) which are structurally closely related to CPDHC (1) showed no inhibitory effects on the IL-6-induced SEAP expression in HepG2 cells. Studies on the mode of action revealed that CPDHC (1) affects the IL-6-dependent pathway by inhibiting the tyrosine phosphorylation of the STAT3 and STAT1 as well as the serine phosphorylation of the Stat3 transcription factor. In addition, CPDHC (1) and DHPC (2) inhibit the AP-1 and NF-kappaB mediated SEAP expression in transiently transfected HeLa S3 cells with IC(50) values of 10-15 microM (2-3 microg/ml) and 50-100 microM (8-16 microg/ml) respectively. Our results indicate that CPDHC inhibits the NF-kappaB pathway by preventing the phosphorylation and proteolytic degradation of the IkappaBalpha protein. The novel cyclopentenones may represent lead compounds for the development of new anti-inflammatory drugs." @default.
• W2090521110 created "2016-06-24" @default.
• W2090521110 creator A5001863363 @default.
• W2090521110 creator A5010153592 @default.
• W2090521110 creator A5011961568 @default.
• W2090521110 creator A5024499741 @default.
• W2090521110 date "2000-09-01" @default.
• W2090521110 modified "2023-09-24" @default.
• W2090521110 title "Inhibition of Interleukin-6 Signaling and Stat3 Activation by a New Class of Bioactive Cyclopentenone Derivatives" @default.
• W2090521110 cites W1528756081 @default.
• W2090521110 cites W1777081626 @default.
• W2090521110 cites W1779691448 @default.
• W2090521110 cites W1822742523 @default.
• W2090521110 cites W185068922 @default.
• W2090521110 cites W1971731547 @default.
• W2090521110 cites W1971908211 @default.
• W2090521110 cites W1974486772 @default.
• W2090521110 cites W1984486504 @default.
• W2090521110 cites W1990718562 @default.
• W2090521110 cites W1996267589 @default.
• W2090521110 cites W1996286392 @default.
• W2090521110 cites W1997785224 @default.
• W2090521110 cites W2000786327 @default.
• W2090521110 cites W2004179579 @default.
• W2090521110 cites W2026403124 @default.
• W2090521110 cites W2036452124 @default.
• W2090521110 cites W2052747333 @default.
• W2090521110 cites W2059405728 @default.
• W2090521110 cites W2063423888 @default.
• W2090521110 cites W2073993982 @default.
• W2090521110 cites W2086715846 @default.
• W2090521110 cites W2090832347 @default.
• W2090521110 cites W2091695331 @default.
• W2090521110 cites W2096665268 @default.
• W2090521110 cites W2103565638 @default.
• W2090521110 cites W2131656392 @default.
• W2090521110 cites W2132633540 @default.
• W2090521110 cites W2135392289 @default.
• W2090521110 cites W2151892297 @default.
• W2090521110 cites W2173560213 @default.
• W2090521110 cites W2312657304 @default.
• W2090521110 cites W4249448146 @default.
• W2090521110 doi "https://doi.org/10.1006/bbrc.2000.3499" @default.
• W2090521110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11027495" @default.
• W2090521110 hasPublicationYear "2000" @default.
• W2090521110 type Work @default.
• W2090521110 sameAs 2090521110 @default.
• W2090521110 citedByCount "23" @default.
• W2090521110 countsByYear W20905211102012 @default.
• W2090521110 countsByYear W20905211102013 @default.
• W2090521110 countsByYear W20905211102014 @default.
• W2090521110 countsByYear W20905211102015 @default.
• W2090521110 countsByYear W20905211102016 @default.
• W2090521110 countsByYear W20905211102017 @default.
• W2090521110 countsByYear W20905211102020 @default.
• W2090521110 countsByYear W20905211102022 @default.
• W2090521110 crossrefType "journal-article" @default.
• W2090521110 hasAuthorship W2090521110A5001863363 @default.
• W2090521110 hasAuthorship W2090521110A5010153592 @default.
• W2090521110 hasAuthorship W2090521110A5011961568 @default.
• W2090521110 hasAuthorship W2090521110A5024499741 @default.
• W2090521110 hasConcept C11960822 @default.
• W2090521110 hasConcept C153911025 @default.
• W2090521110 hasConcept C178666793 @default.
• W2090521110 hasConcept C185592680 @default.
• W2090521110 hasConcept C2777003663 @default.
• W2090521110 hasConcept C2777553839 @default.
• W2090521110 hasConcept C2779746879 @default.
• W2090521110 hasConcept C55493867 @default.
• W2090521110 hasConcept C62478195 @default.
• W2090521110 hasConcept C71240020 @default.
• W2090521110 hasConcept C86803240 @default.
• W2090521110 hasConceptScore W2090521110C11960822 @default.
• W2090521110 hasConceptScore W2090521110C153911025 @default.
• W2090521110 hasConceptScore W2090521110C178666793 @default.
• W2090521110 hasConceptScore W2090521110C185592680 @default.
• W2090521110 hasConceptScore W2090521110C2777003663 @default.
• W2090521110 hasConceptScore W2090521110C2777553839 @default.
• W2090521110 hasConceptScore W2090521110C2779746879 @default.
• W2090521110 hasConceptScore W2090521110C55493867 @default.
• W2090521110 hasConceptScore W2090521110C62478195 @default.
• W2090521110 hasConceptScore W2090521110C71240020 @default.
• W2090521110 hasConceptScore W2090521110C86803240 @default.
• W2090521110 hasIssue "2" @default.
• W2090521110 hasLocation W20905211101 @default.
• W2090521110 hasLocation W20905211102 @default.
• W2090521110 hasOpenAccess W2090521110 @default.
• W2090521110 hasPrimaryLocation W20905211101 @default.
• W2090521110 hasRelatedWork W174927118 @default.
• W2090521110 hasRelatedWork W1892781835 @default.
• W2090521110 hasRelatedWork W1969661574 @default.
• W2090521110 hasRelatedWork W1985881439 @default.
• W2090521110 hasRelatedWork W1995690959 @default.
• W2090521110 hasRelatedWork W2040318963 @default.
• W2090521110 hasRelatedWork W2094732767 @default.
• W2090521110 hasRelatedWork W2140594956 @default.
• W2090521110 hasRelatedWork W2163887454 @default.
• W2090521110 hasRelatedWork W2530220159 @default.

• next