FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090522013> ?p ?o ?g. }

• W2090522013 endingPage "1042" @default.
• W2090522013 startingPage "1037" @default.
• W2090522013 abstract "The mechanism of hydrolysis of the apurinic/apyrimidinic (AP) site and its synthetic analogs by using tyrosyl-DNA phosphodiesterase 1 (Tdp1) was analyzed. Tdp1 catalyzes the cleavage of AP site and the synthetic analog of the AP site, 3-hydroxy-2(hydroxymethyl)-tetrahydrofuran (THF), in DNA by hydrolysis of the phosphodiester bond between the substituent and 5' adjacent phosphate. The product of Tdp1 cleavage in the case of the AP site is unstable and is hydrolyzed with the formation of 3'- and 5'-margin phosphates. The following repair demands the ordered action of polynucleotide kinase phosphorylase, with XRCC1, DNA polymerase β, and DNA ligase. In the case of THF, Tdp1 generates break with the 5'-THF and the 3'-phosphate termini. Tdp1 is also able to effectively cleave non-nucleotide insertions in DNA, decanediol and diethyleneglycol moieties by the same mechanism as in the case of THF cleavage. The efficiency of Tdp1 catalyzed hydrolysis of AP-site analog correlates with the DNA helix distortion induced by the substituent. The following repair of 5'-THF and other AP-site analogs can be processed by the long-patch base excision repair pathway." @default.
• W2090522013 created "2016-06-24" @default.
• W2090522013 creator A5001007906 @default.
• W2090522013 creator A5003204998 @default.
• W2090522013 creator A5064506934 @default.
• W2090522013 creator A5085712207 @default.
• W2090522013 creator A5091899030 @default.
• W2090522013 date "2013-12-01" @default.
• W2090522013 modified "2023-10-14" @default.
• W2090522013 title "The mechanism of human tyrosyl-DNA phosphodiesterase 1 in the cleavage of AP site and its synthetic analogs" @default.
• W2090522013 cites W1970145377 @default.
• W2090522013 cites W1992809685 @default.
• W2090522013 cites W2004185923 @default.
• W2090522013 cites W2005110566 @default.
• W2090522013 cites W2015463397 @default.
• W2090522013 cites W2021241545 @default.
• W2090522013 cites W2026233878 @default.
• W2090522013 cites W2028480368 @default.
• W2090522013 cites W2028876509 @default.
• W2090522013 cites W2052036700 @default.
• W2090522013 cites W2059693060 @default.
• W2090522013 cites W2072358340 @default.
• W2090522013 cites W2072695826 @default.
• W2090522013 cites W2074916944 @default.
• W2090522013 cites W2076418100 @default.
• W2090522013 cites W2079373465 @default.
• W2090522013 cites W2082761467 @default.
• W2090522013 cites W2094256512 @default.
• W2090522013 cites W2098103986 @default.
• W2090522013 cites W2118970748 @default.
• W2090522013 cites W2119090392 @default.
• W2090522013 cites W2122481742 @default.
• W2090522013 cites W2127698844 @default.
• W2090522013 cites W2136820636 @default.
• W2090522013 cites W2167505302 @default.
• W2090522013 doi "https://doi.org/10.1016/j.dnarep.2013.09.008" @default.
• W2090522013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24183900" @default.
• W2090522013 hasPublicationYear "2013" @default.
• W2090522013 type Work @default.
• W2090522013 sameAs 2090522013 @default.
• W2090522013 citedByCount "37" @default.
• W2090522013 countsByYear W20905220132014 @default.
• W2090522013 countsByYear W20905220132015 @default.
• W2090522013 countsByYear W20905220132016 @default.
• W2090522013 countsByYear W20905220132017 @default.
• W2090522013 countsByYear W20905220132018 @default.
• W2090522013 countsByYear W20905220132019 @default.
• W2090522013 countsByYear W20905220132020 @default.
• W2090522013 countsByYear W20905220132021 @default.
• W2090522013 countsByYear W20905220132023 @default.
• W2090522013 crossrefType "journal-article" @default.
• W2090522013 hasAuthorship W2090522013A5001007906 @default.
• W2090522013 hasAuthorship W2090522013A5003204998 @default.
• W2090522013 hasAuthorship W2090522013A5064506934 @default.
• W2090522013 hasAuthorship W2090522013A5085712207 @default.
• W2090522013 hasAuthorship W2090522013A5091899030 @default.
• W2090522013 hasConcept C1009745 @default.
• W2090522013 hasConcept C104317684 @default.
• W2090522013 hasConcept C134935766 @default.
• W2090522013 hasConcept C150777479 @default.
• W2090522013 hasConcept C175114707 @default.
• W2090522013 hasConcept C181199279 @default.
• W2090522013 hasConcept C185592680 @default.
• W2090522013 hasConcept C192396546 @default.
• W2090522013 hasConcept C2756471 @default.
• W2090522013 hasConcept C38441620 @default.
• W2090522013 hasConcept C41183919 @default.
• W2090522013 hasConcept C552990157 @default.
• W2090522013 hasConcept C55493867 @default.
• W2090522013 hasConcept C67705224 @default.
• W2090522013 hasConcept C71240020 @default.
• W2090522013 hasConcept C86803240 @default.
• W2090522013 hasConceptScore W2090522013C1009745 @default.
• W2090522013 hasConceptScore W2090522013C104317684 @default.
• W2090522013 hasConceptScore W2090522013C134935766 @default.
• W2090522013 hasConceptScore W2090522013C150777479 @default.
• W2090522013 hasConceptScore W2090522013C175114707 @default.
• W2090522013 hasConceptScore W2090522013C181199279 @default.
• W2090522013 hasConceptScore W2090522013C185592680 @default.
• W2090522013 hasConceptScore W2090522013C192396546 @default.
• W2090522013 hasConceptScore W2090522013C2756471 @default.
• W2090522013 hasConceptScore W2090522013C38441620 @default.
• W2090522013 hasConceptScore W2090522013C41183919 @default.
• W2090522013 hasConceptScore W2090522013C552990157 @default.
• W2090522013 hasConceptScore W2090522013C55493867 @default.
• W2090522013 hasConceptScore W2090522013C67705224 @default.
• W2090522013 hasConceptScore W2090522013C71240020 @default.
• W2090522013 hasConceptScore W2090522013C86803240 @default.
• W2090522013 hasFunder F4320321079 @default.
• W2090522013 hasFunder F4320322646 @default.
• W2090522013 hasIssue "12" @default.
• W2090522013 hasLocation W20905220131 @default.
• W2090522013 hasLocation W20905220132 @default.
• W2090522013 hasLocation W20905220133 @default.
• W2090522013 hasLocation W20905220134 @default.
• W2090522013 hasOpenAccess W2090522013 @default.
• W2090522013 hasPrimaryLocation W20905220131 @default.
• W2090522013 hasRelatedWork W134870157 @default.

• next