Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090537330> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2090537330 endingPage "716" @default.
- W2090537330 startingPage "706" @default.
- W2090537330 abstract "In this article, details of crystal and molecular structures of sunitinib malate (SUM), an anticancer therapeutic, and its key synthetic intermediate are presented. Both these compounds were also characterized spectroscopically and thermally. SUM crystallizes in the monoclinic P21 space group with two molecules in the asymmetric part of the unit cell, whereas the intermediate crystallises in the triclinic P-1 space group with four independent molecules in the asymmetric unit. The three-dimensional structure of SUM consists of two different layers of molecules. The first one is built of the malic anions, whereas the other layer consists of more hydrophobic sunitinib molecules. This layer is formed by two types of molecules creating a herring bond-like pattern with pairs of neighboring cations forming the V-shape arrangement of molecules. The V-shaped pairs of molecules form ribbons by fitting into two neighboring V shapes. The characteristic V-shape assemble of the moieties is hold together with three C-H…F weak interactions. Besides, process-related impurities of SUM were identified and their structures confirmed by separate synthesis. These impurities were fully characterized by spectroscopic and crystallographic methods as well as by differential scanning calorimetry and thermogravimetric analysis. The H-, 13C-, and 15N-nuclear magnetic resonance signals were fully assigned structurally and the resulting structures were confirmed by Fourier-transformed infrared spectroscopy. It was the herein elaborated synthesis of impurity-free SUM that allowed for growing of its single crystals suitable for X-ray crystallographic studies. Comparison of the powder X-ray diffraction pattern for SUM with that derived from single-crystal X-ray crystallographic analysis indicated that SUM formed the polymorph I crystal phase, which is also encountered in its pharmaceutical formulation. © 2012 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:706–716, 2013" @default.
- W2090537330 created "2016-06-24" @default.
- W2090537330 creator A5005051037 @default.
- W2090537330 creator A5014509785 @default.
- W2090537330 creator A5026415431 @default.
- W2090537330 creator A5027049693 @default.
- W2090537330 creator A5046396980 @default.
- W2090537330 creator A5052033965 @default.
- W2090537330 creator A5053563444 @default.
- W2090537330 creator A5063136001 @default.
- W2090537330 creator A5071412549 @default.
- W2090537330 creator A5090391240 @default.
- W2090537330 date "2013-02-01" @default.
- W2090537330 modified "2023-10-16" @default.
- W2090537330 title "Physicochemical Characteristics of Sunitinib Malate and its Process-Related Impurities" @default.
- W2090537330 cites W1831380443 @default.
- W2090537330 cites W1974556146 @default.
- W2090537330 cites W2054686043 @default.
- W2090537330 cites W2059020082 @default.
- W2090537330 cites W2059499441 @default.
- W2090537330 cites W2074415344 @default.
- W2090537330 cites W2110509198 @default.
- W2090537330 cites W2131350133 @default.
- W2090537330 cites W2139511378 @default.
- W2090537330 cites W2149413656 @default.
- W2090537330 cites W2158474413 @default.
- W2090537330 cites W2166456106 @default.
- W2090537330 cites W2325751105 @default.
- W2090537330 doi "https://doi.org/10.1002/jps.23412" @default.
- W2090537330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23233239" @default.
- W2090537330 hasPublicationYear "2013" @default.
- W2090537330 type Work @default.
- W2090537330 sameAs 2090537330 @default.
- W2090537330 citedByCount "15" @default.
- W2090537330 countsByYear W20905373302014 @default.
- W2090537330 countsByYear W20905373302015 @default.
- W2090537330 countsByYear W20905373302016 @default.
- W2090537330 countsByYear W20905373302017 @default.
- W2090537330 countsByYear W20905373302018 @default.
- W2090537330 countsByYear W20905373302019 @default.
- W2090537330 countsByYear W20905373302020 @default.
- W2090537330 countsByYear W20905373302022 @default.
- W2090537330 crossrefType "journal-article" @default.
- W2090537330 hasAuthorship W2090537330A5005051037 @default.
- W2090537330 hasAuthorship W2090537330A5014509785 @default.
- W2090537330 hasAuthorship W2090537330A5026415431 @default.
- W2090537330 hasAuthorship W2090537330A5027049693 @default.
- W2090537330 hasAuthorship W2090537330A5046396980 @default.
- W2090537330 hasAuthorship W2090537330A5052033965 @default.
- W2090537330 hasAuthorship W2090537330A5053563444 @default.
- W2090537330 hasAuthorship W2090537330A5063136001 @default.
- W2090537330 hasAuthorship W2090537330A5071412549 @default.
- W2090537330 hasAuthorship W2090537330A5090391240 @default.
- W2090537330 hasConcept C115624301 @default.
- W2090537330 hasConcept C153642686 @default.
- W2090537330 hasConcept C178790620 @default.
- W2090537330 hasConcept C185592680 @default.
- W2090537330 hasConcept C32909587 @default.
- W2090537330 hasConcept C42228675 @default.
- W2090537330 hasConcept C61276311 @default.
- W2090537330 hasConcept C8010536 @default.
- W2090537330 hasConceptScore W2090537330C115624301 @default.
- W2090537330 hasConceptScore W2090537330C153642686 @default.
- W2090537330 hasConceptScore W2090537330C178790620 @default.
- W2090537330 hasConceptScore W2090537330C185592680 @default.
- W2090537330 hasConceptScore W2090537330C32909587 @default.
- W2090537330 hasConceptScore W2090537330C42228675 @default.
- W2090537330 hasConceptScore W2090537330C61276311 @default.
- W2090537330 hasConceptScore W2090537330C8010536 @default.
- W2090537330 hasIssue "2" @default.
- W2090537330 hasLocation W20905373301 @default.
- W2090537330 hasLocation W20905373302 @default.
- W2090537330 hasOpenAccess W2090537330 @default.
- W2090537330 hasPrimaryLocation W20905373301 @default.
- W2090537330 hasRelatedWork W133123517 @default.
- W2090537330 hasRelatedWork W2003470303 @default.
- W2090537330 hasRelatedWork W2089189525 @default.
- W2090537330 hasRelatedWork W2109585060 @default.
- W2090537330 hasRelatedWork W2123678093 @default.
- W2090537330 hasRelatedWork W2313491344 @default.
- W2090537330 hasRelatedWork W2353894671 @default.
- W2090537330 hasRelatedWork W2989296875 @default.
- W2090537330 hasRelatedWork W3148785330 @default.
- W2090537330 hasRelatedWork W365863234 @default.
- W2090537330 hasVolume "102" @default.
- W2090537330 isParatext "false" @default.
- W2090537330 isRetracted "false" @default.
- W2090537330 magId "2090537330" @default.
- W2090537330 workType "article" @default.