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- W2090542543 abstract "Objective: To examine the effectiveness of gabapentinoids (gabapentin and pregabalin) in improving neuropathic pain in individuals with spinal cord injury (SCI). Data Source: A systematic search was conducted using Medline, CINAHL, EMBASE, and PsycINFO databases for all relevant articles published between 1980 to March 2010. Study Selection: Randomized controlled trials (RCTs) involving gabapentinoids in the treatment of neuropathic pain post-SCI, with at least 3 individuals with SCI and 50% or more of study population with SCI. Data Extraction: 2 independent reviewers assessed study quality using the PEDro assessment scale. Study results were pooled using a random effects model. Hedge's g was used to calculate standardized mean difference (±SE, 95% confidence interval (CI)) for the posttreatment effect on pain intensity assessed in intervention versus control groups for each study. Effect sizes are commonly interpreted as: small=0.2, moderate=0.5, large=0.8. Data Synthesis: 5 RCTs (3 crossover and 2 parallel study designs) met inclusion criteria providing a total pooled sample size of 226 individuals. Pooled analysis demonstrated a significant reduction in the intensity of neuropathic pain associated with gabapentinoid treatment compared to placebo. The pooled SMD was 0.797±0.114 (95% CI, 0.574–1.02; P=.0001). Funnel plot analysis revealed no significant publication bias (Egger's regression intercept=x; P=.67). Conclusions: The results of the meta-analysis demonstrate that treatment with gabapentinoids is associated with reduction in intensity of neuropathic pain post-SCI." @default.
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- W2090542543 date "2010-10-01" @default.
- W2090542543 modified "2023-10-14" @default.
- W2090542543 title "Poster 44: Effectiveness of Gabapentinoids in Decreasing Neuropathic Pain Intensity Postspinal Cord Injury: A Meta-Analysis" @default.
- W2090542543 doi "https://doi.org/10.1016/j.apmr.2010.07.071" @default.
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