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• W2090542810 abstract "Évaluer la survenue des effets indésirables lors de la chimioprophylaxie antipaludéenne au niveau du contingent marocain en République Démocratique du Congo (RDC). L’enquête de type transversal, concerne les militaires du contingent marocain en RDC. Elle est réalisée via un questionnaire rempli par une équipe médicale pluridisciplinaire interrogeant les sujets dans tous les sites et les postes avancés militaires accessibles pendant la période de l’étude. L’étude concerne 362 militaires de sexe masculin. 94 sujets (soit 25,7 %) ont déclaré un ou plusieurs effets indésirables. Ces effets sont de nature neuropsychiatrique (anxiété, irritabilité, vertiges…) [n = 76], digestive (anorexie, diarrhées, nausées…) [n = 42], cardiovasculaire (tachycardie, palpitations, précordialgies) [n = 5], musculosquelettique (arthralgie, crampes) [n = 4], cutanée (érythème, purpura) [n = 2], ou autres (n = 13). Aucun effet indésirable « inattendu » ou « grave » n’a été déclaré. L’imputabilité est « douteuse » pour 80 cas, « plausible » pour 12 cas et « vraisemblable » pour deux cas. Les enquêtés ayant des fonctions médicales et paramédicales déclarent plus d’effets indésirables. Lors de notre étude, la méfloquine a provoqué des effets indésirables chez un quart des sujets la recevant. La plupart des effets indésirables sont de nature neuropsychiatrique ; aucun cas d’effet indésirable « grave » n’a été relevé ce qui renforce l’intérêt de son utilisation en curatif et en préventif même pendant des traitements de prophylaxie de longue durée. Abstract– Long-Term Malaria Prophylaxis with Mefloquine: a Study of Adverse Drug Reactions. To estimate the relative frequency of reported adverse drug reactions during the malaria chemoprophylactic period of the Moroccan contingent in Democratic Republic of Congo (DRC). The transversal survey involved all military personnel of the Moroccan contingent and was carried out using a questionnaire to be filled out by a multidisciplinary medical team. It was performed in all the military sites and the advanced posts accessible during the period of the study. The study involved 362 male military subjects. Ninety-four adverse drug reactions were described: neuropsychiatric (anxiety, irritability, dizziness…) [n=76], digestive (anorexia, diarrhea, nausea…) [n=42], cardiovascular (tachycardia, palpitation, precordialgia…) [n=5], musculoskeletal (arthralgia, cramps) [n=4], cutaneous (redness, purpura) [n=2], and other (n=13). No “unexpected” or “serious” adverse drug reaction was reported. The causality assessment score was determined in 94 cases. Two of these reports were rated “likely”, 12 “possible” and 80 doubtful. More adverse drug reactions were reported by subjects having medical and paramedical functions. During our study, mefloquine induced adverse drug reactions in a quarter of the treated subjects. Most of the adverse drug reactions were neuropsychiatric. No “serious” adverse drug reactions were reported underlying the interest of its use, even for long-term chemoprophylaxis." @default.
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• W2090542810 date "2010-09-01" @default.
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• W2090542810 title "Chimioprophylaxie de longue durée à la méfloquine : étude des effets indésirables" @default.
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• W2090542810 doi "https://doi.org/10.2515/therapie/2010049" @default.
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