Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090557792> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2090557792 endingPage "300" @default.
- W2090557792 startingPage "294" @default.
- W2090557792 abstract "Clusterin/apolipoprotein J (CLU) is a conserved, ubiquitously expressed secreted glycoprotein that has been implicated in several physiological processes and was found to accumulate in many severe physiological disturbances. We have previously shown that the CLU gene and protein are upregulated during replicative senescence, stress-induced premature senescence, in vivo aging, and in several age-related diseases. In this study we have examined the CLU gene relationship to human longevity. We recruited and further analyzed 96 blood samples from Italian and Greek healthy donors of different ages, including 49 centenarians. We found that although the CLU gene expression levels increase during aging, in the centenarians' samples CLU levels were lower than those found in old donors. We then investigated the possible existence of a genetic polymorphism related to longevity at the CLU structural locus. A neutral noncoding sequence variant was detected 35 nucleotides upstream from exon 6, which does not correlate, however, with the age of the donor. We conclude that CLU gene accumulation during in vivo aging does not directly relate to chronological age, but rather indicates increased levels of organismal stress due to a progressive failure of homeostasis and/or to prolonged exposure to a stressful environment." @default.
- W2090557792 created "2016-06-24" @default.
- W2090557792 creator A5038570947 @default.
- W2090557792 date "2006-05-01" @default.
- W2090557792 modified "2023-09-23" @default.
- W2090557792 title "Reduced Expression Levels of the Senescence Biomarker Clusterin/Apolipoprotein J in Lymphocytes from Healthy Centenarians" @default.
- W2090557792 cites W189012360 @default.
- W2090557792 cites W1978480398 @default.
- W2090557792 cites W2009043082 @default.
- W2090557792 cites W2023352438 @default.
- W2090557792 cites W2035048988 @default.
- W2090557792 cites W2038035925 @default.
- W2090557792 cites W2038354418 @default.
- W2090557792 cites W2042661801 @default.
- W2090557792 cites W2066032782 @default.
- W2090557792 cites W2069863984 @default.
- W2090557792 cites W2069943574 @default.
- W2090557792 cites W2070205590 @default.
- W2090557792 cites W2084528656 @default.
- W2090557792 cites W2095286897 @default.
- W2090557792 cites W2134657352 @default.
- W2090557792 cites W2135574649 @default.
- W2090557792 cites W2144429901 @default.
- W2090557792 cites W2166575679 @default.
- W2090557792 doi "https://doi.org/10.1196/annals.1354.039" @default.
- W2090557792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16804001" @default.
- W2090557792 hasPublicationYear "2006" @default.
- W2090557792 type Work @default.
- W2090557792 sameAs 2090557792 @default.
- W2090557792 citedByCount "15" @default.
- W2090557792 countsByYear W20905577922014 @default.
- W2090557792 countsByYear W20905577922015 @default.
- W2090557792 countsByYear W20905577922019 @default.
- W2090557792 countsByYear W20905577922021 @default.
- W2090557792 countsByYear W20905577922022 @default.
- W2090557792 countsByYear W20905577922023 @default.
- W2090557792 crossrefType "journal-article" @default.
- W2090557792 hasAuthorship W2090557792A5038570947 @default.
- W2090557792 hasConcept C104317684 @default.
- W2090557792 hasConcept C127561419 @default.
- W2090557792 hasConcept C134018914 @default.
- W2090557792 hasConcept C150194340 @default.
- W2090557792 hasConcept C177336024 @default.
- W2090557792 hasConcept C190283241 @default.
- W2090557792 hasConcept C2776759703 @default.
- W2090557792 hasConcept C2778163477 @default.
- W2090557792 hasConcept C2779476363 @default.
- W2090557792 hasConcept C2781197716 @default.
- W2090557792 hasConcept C500499127 @default.
- W2090557792 hasConcept C522857546 @default.
- W2090557792 hasConcept C54355233 @default.
- W2090557792 hasConcept C62746215 @default.
- W2090557792 hasConcept C84597430 @default.
- W2090557792 hasConcept C86803240 @default.
- W2090557792 hasConceptScore W2090557792C104317684 @default.
- W2090557792 hasConceptScore W2090557792C127561419 @default.
- W2090557792 hasConceptScore W2090557792C134018914 @default.
- W2090557792 hasConceptScore W2090557792C150194340 @default.
- W2090557792 hasConceptScore W2090557792C177336024 @default.
- W2090557792 hasConceptScore W2090557792C190283241 @default.
- W2090557792 hasConceptScore W2090557792C2776759703 @default.
- W2090557792 hasConceptScore W2090557792C2778163477 @default.
- W2090557792 hasConceptScore W2090557792C2779476363 @default.
- W2090557792 hasConceptScore W2090557792C2781197716 @default.
- W2090557792 hasConceptScore W2090557792C500499127 @default.
- W2090557792 hasConceptScore W2090557792C522857546 @default.
- W2090557792 hasConceptScore W2090557792C54355233 @default.
- W2090557792 hasConceptScore W2090557792C62746215 @default.
- W2090557792 hasConceptScore W2090557792C84597430 @default.
- W2090557792 hasConceptScore W2090557792C86803240 @default.
- W2090557792 hasIssue "1" @default.
- W2090557792 hasLocation W20905577921 @default.
- W2090557792 hasLocation W20905577922 @default.
- W2090557792 hasOpenAccess W2090557792 @default.
- W2090557792 hasPrimaryLocation W20905577921 @default.
- W2090557792 hasRelatedWork W1984707167 @default.
- W2090557792 hasRelatedWork W2028087115 @default.
- W2090557792 hasRelatedWork W2051875300 @default.
- W2090557792 hasRelatedWork W2057739827 @default.
- W2090557792 hasRelatedWork W2059190566 @default.
- W2090557792 hasRelatedWork W2911635622 @default.
- W2090557792 hasRelatedWork W2953478896 @default.
- W2090557792 hasRelatedWork W3209949350 @default.
- W2090557792 hasRelatedWork W4213091566 @default.
- W2090557792 hasRelatedWork W59844759 @default.
- W2090557792 hasVolume "1067" @default.
- W2090557792 isParatext "false" @default.
- W2090557792 isRetracted "false" @default.
- W2090557792 magId "2090557792" @default.
- W2090557792 workType "article" @default.