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- W2090560923 abstract "Immunoglobulin genes are generated during differentiation of B lymphocytes by joining gene segments. A mouse pre-B cell contains a functional immunoglobulin heavy-chain gene, but no light-chain gene. Although there is only one heavy-chain locus, there are two light-chain loci: kappa and lambda. It has been reported that kappa loci in the germ-line configuration are never (in man) or very rarely (in the mouse) present in cells with functionally rearranged lambda-chain genes. Two explanations have been proposed to explain this: (a) the ordered rearrangement theory, which postulates that light-chain gene rearrangement in the pre-B cell is first attempted at the kappa locus, and that only upon failure to produce a functional kappa chain is there an attempt to rearrange the lambda locus; and (b) the stochastic theory, which postulates that rearrangement at the lambda locus proceeds at a rate that is intrinsically much slower than that at the kappa locus. We show here that lambda-chain genes are generated whether or not the kappa locus has lost its germ-line arrangement, a result that is compatible only with the stochastic theory." @default.
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- W2090560923 date "1990-01-01" @default.
- W2090560923 modified "2023-10-17" @default.
- W2090560923 title "Immunoglobulin<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E1><mml:mi>λ</mml:mi></mml:math>Gene Rearrangement Can Precede<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=E2><mml:mi>κ</mml:mi></mml:math>Gene Rearrangement" @default.
- W2090560923 doi "https://doi.org/10.1155/1990/56014" @default.
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