FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090561131> ?p ?o ?g. }

• W2090561131 endingPage "40" @default.
• W2090561131 startingPage "36" @default.
• W2090561131 abstract "We reported an independent association of the short variant of the serotonin transporter gene-linked polymorphic region (SERTPR) and tryptophan hydroxylase (TPH) genes with antidepressant response to selective serotonin reuptake inhibitors (SSRIs). The aim of the present study was to confirm the effect of the SERTPR and TPH gene variants on the SSRIs antidepressant activity in a new sample of major and bipolar depressives. Two hundred and twenty one inpatients (major depressives = 128, bipolar disorder = 93) were treated with SSRIs (fluvoxamine or paroxetine) for 6 weeks; the severity of depressive symptoms was weekly assessed with the Hamilton Rating Scale for Depression (HAMD). SERTPR and TPH variants were determined using PCR-based techniques, 220 subjects genotyped for SERTPR and 221 for TPH that were never included in previous studies. SERTPR*s/s variant association with a poor response to SSRI treatment was confirmed, even if with less significant P values (P = 0.034), independently from clinical variables; pooling the present sample with previous ones we observed a highly significant effect (P < 0.000001). TPH*A/A variants showed higher HAMD scores throughout the trial but with only a trend in the same direction of our previous study in terms of a worse response of A/A genotypes. Thus, the previous positive association was not fully replicated for TPH. The present independent replication confirms SERTPR variants as a liability factor for antidepressant efficacy while the TPH effect is not unequivocal. © 2004 Wiley-Liss, Inc." @default.
• W2090561131 created "2016-06-24" @default.
• W2090561131 creator A5020986794 @default.
• W2090561131 creator A5035112958 @default.
• W2090561131 creator A5046621609 @default.
• W2090561131 creator A5070360587 @default.
• W2090561131 creator A5079520465 @default.
• W2090561131 creator A5090184049 @default.
• W2090561131 date "2004-01-01" @default.
• W2090561131 modified "2023-10-18" @default.
• W2090561131 title "Further evidence of a combined effect of SERTPR and TPH on SSRIs response in mood disorders" @default.
• W2090561131 cites W1965260540 @default.
• W2090561131 cites W1966000037 @default.
• W2090561131 cites W1970674565 @default.
• W2090561131 cites W1996455672 @default.
• W2090561131 cites W1999246748 @default.
• W2090561131 cites W2004424937 @default.
• W2090561131 cites W2005534453 @default.
• W2090561131 cites W2008709814 @default.
• W2090561131 cites W2014813076 @default.
• W2090561131 cites W2020361307 @default.
• W2090561131 cites W2025773780 @default.
• W2090561131 cites W2030805287 @default.
• W2090561131 cites W2039230966 @default.
• W2090561131 cites W2039262765 @default.
• W2090561131 cites W2043175890 @default.
• W2090561131 cites W2043557429 @default.
• W2090561131 cites W2045020364 @default.
• W2090561131 cites W204854131 @default.
• W2090561131 cites W2061378977 @default.
• W2090561131 cites W2063473805 @default.
• W2090561131 cites W2065592421 @default.
• W2090561131 cites W2070413556 @default.
• W2090561131 cites W2070861572 @default.
• W2090561131 cites W2071952197 @default.
• W2090561131 cites W2098760758 @default.
• W2090561131 cites W2106095564 @default.
• W2090561131 cites W2106510562 @default.
• W2090561131 cites W2111424618 @default.
• W2090561131 cites W2116152046 @default.
• W2090561131 cites W2136749432 @default.
• W2090561131 cites W2321329826 @default.
• W2090561131 cites W2329661970 @default.
• W2090561131 cites W2410025091 @default.
• W2090561131 cites W588687509 @default.
• W2090561131 doi "https://doi.org/10.1002/ajmg.b.30027" @default.
• W2090561131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15274037" @default.
• W2090561131 hasPublicationYear "2004" @default.
• W2090561131 type Work @default.
• W2090561131 sameAs 2090561131 @default.
• W2090561131 citedByCount "65" @default.
• W2090561131 countsByYear W20905611312012 @default.
• W2090561131 countsByYear W20905611312013 @default.
• W2090561131 countsByYear W20905611312014 @default.
• W2090561131 countsByYear W20905611312015 @default.
• W2090561131 countsByYear W20905611312016 @default.
• W2090561131 countsByYear W20905611312017 @default.
• W2090561131 countsByYear W20905611312018 @default.
• W2090561131 countsByYear W20905611312019 @default.
• W2090561131 countsByYear W20905611312020 @default.
• W2090561131 countsByYear W20905611312021 @default.
• W2090561131 crossrefType "journal-article" @default.
• W2090561131 hasAuthorship W2090561131A5020986794 @default.
• W2090561131 hasAuthorship W2090561131A5035112958 @default.
• W2090561131 hasAuthorship W2090561131A5046621609 @default.
• W2090561131 hasAuthorship W2090561131A5070360587 @default.
• W2090561131 hasAuthorship W2090561131A5079520465 @default.
• W2090561131 hasAuthorship W2090561131A5090184049 @default.
• W2090561131 hasConcept C118552586 @default.
• W2090561131 hasConcept C126322002 @default.
• W2090561131 hasConcept C15744967 @default.
• W2090561131 hasConcept C170493617 @default.
• W2090561131 hasConcept C2775864247 @default.
• W2090561131 hasConcept C2775951788 @default.
• W2090561131 hasConcept C2776134451 @default.
• W2090561131 hasConcept C2776174506 @default.
• W2090561131 hasConcept C2776466505 @default.
• W2090561131 hasConcept C2777134132 @default.
• W2090561131 hasConcept C2777198177 @default.
• W2090561131 hasConcept C2777490545 @default.
• W2090561131 hasConcept C2777828372 @default.
• W2090561131 hasConcept C2778897192 @default.
• W2090561131 hasConcept C2779177272 @default.
• W2090561131 hasConcept C2779910183 @default.
• W2090561131 hasConcept C2780051608 @default.
• W2090561131 hasConcept C2780733359 @default.
• W2090561131 hasConcept C37000724 @default.
• W2090561131 hasConcept C558461103 @default.
• W2090561131 hasConcept C71924100 @default.
• W2090561131 hasConceptScore W2090561131C118552586 @default.
• W2090561131 hasConceptScore W2090561131C126322002 @default.
• W2090561131 hasConceptScore W2090561131C15744967 @default.
• W2090561131 hasConceptScore W2090561131C170493617 @default.
• W2090561131 hasConceptScore W2090561131C2775864247 @default.
• W2090561131 hasConceptScore W2090561131C2775951788 @default.
• W2090561131 hasConceptScore W2090561131C2776134451 @default.
• W2090561131 hasConceptScore W2090561131C2776174506 @default.
• W2090561131 hasConceptScore W2090561131C2776466505 @default.

• next