FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090561982> ?p ?o ?g. }

• W2090561982 endingPage "523" @default.
• W2090561982 startingPage "513" @default.
• W2090561982 abstract "1. Prostanoid receptor-mediated sensitization, or excitation, of sensory nerve fibres contributes to the generation of hyperalgesia. To characterize the prostanoid receptors present on sensory neurones, biochemical assays were performed on primary cultures of adult rat dorsal root ganglia (DRG) and the F-11 (embryonic rat DRG x neuroblastoma hybrid) cell line. 2. In DRG cultures, the IP receptor agonists, cicaprost and carbaprostacyclin (cPGI2) stimulated cyclic AMP accumulation. Prostaglandin E2 (PGE2) also increased cyclic AMP levels, but to a lesser extent, while carbocyclic thromboxane A2 (cTxA2), PGD2 and PGF2alpha had negligible effects. The rank order of agonist potency was cicaprost>PGE2=BMY45778=cPGI2=PGI2. In the F-11 cells, the rank order of agonist potency for the stimulation of cyclic AMP accumulation was: cicaprost>iloprost=cPGI2=PGI2=BMY45778>PGE2=cTXA2++ +. In DRG cultures, cicaprost induced significantly more accumulation of inositol phosphates than PGE2. 3. To examine the effects of prostanoids on C-fibre activity, extracellular recordings of d.c. potentials from the rat isolated vagus nerve were made with the 'grease-gap' technique. PGI2 (0.1 nM-10 microM) produced the largest depolarizations of the nerve. The rank order of agonist potency was: PGI2=cPGI2=PGE1>cTXA2>PGE2=PGD2=TXB2>PGF2alpha. 4. Prior depolarization of nerves with either forskolin (10 microM) or phorbol dibutyrate (1 microM) alone significantly reduced the response to PGI2 (10 microM), while simultaneous application of both forskolin and phorbol dibutyrate attenuated PGI2 responses almost completely. 5. Putative EP1 and/or TP receptor-selective antagonists had no effect on the responses to PGI2, cPGI2 or PGE2 in the three preparations studied. 6. Collectively, these data are consistent with a positive coupling of IP receptors to both adenylyl cyclase and phospholipase C in sensory neurones. These findings suggest that IP receptors play a major role in the sensitization of rat sensory neurones." @default.
• W2090561982 created "2016-06-24" @default.
• W2090561982 creator A5026950758 @default.
• W2090561982 creator A5027330002 @default.
• W2090561982 creator A5065315705 @default.
• W2090561982 creator A5072070682 @default.
• W2090561982 creator A5078255099 @default.
• W2090561982 date "1998-06-01" @default.
• W2090561982 modified "2023-10-14" @default.
• W2090561982 title "Characterization of prostanoid receptor-evoked responses in rat sensory neurones" @default.
• W2090561982 cites W1539862553 @default.
• W2090561982 cites W1542045064 @default.
• W2090561982 cites W1583934186 @default.
• W2090561982 cites W1602434848 @default.
• W2090561982 cites W1666619344 @default.
• W2090561982 cites W1715662620 @default.
• W2090561982 cites W1882332667 @default.
• W2090561982 cites W1963575053 @default.
• W2090561982 cites W1965204194 @default.
• W2090561982 cites W1967400785 @default.
• W2090561982 cites W1968844130 @default.
• W2090561982 cites W1972591971 @default.
• W2090561982 cites W1972995848 @default.
• W2090561982 cites W1976774509 @default.
• W2090561982 cites W1978860160 @default.
• W2090561982 cites W1978926613 @default.
• W2090561982 cites W1978939719 @default.
• W2090561982 cites W1980981578 @default.
• W2090561982 cites W1982194458 @default.
• W2090561982 cites W1992700615 @default.
• W2090561982 cites W1992998712 @default.
• W2090561982 cites W1994097645 @default.
• W2090561982 cites W2000468755 @default.
• W2090561982 cites W2003436933 @default.
• W2090561982 cites W2010159487 @default.
• W2090561982 cites W2011781709 @default.
• W2090561982 cites W2013947622 @default.
• W2090561982 cites W2018096295 @default.
• W2090561982 cites W2019378068 @default.
• W2090561982 cites W2020841267 @default.
• W2090561982 cites W2026628889 @default.
• W2090561982 cites W2029591536 @default.
• W2090561982 cites W2030160635 @default.
• W2090561982 cites W2030245254 @default.
• W2090561982 cites W2033457590 @default.
• W2090561982 cites W2034384673 @default.
• W2090561982 cites W2034464856 @default.
• W2090561982 cites W203575579 @default.
• W2090561982 cites W2038945391 @default.
• W2090561982 cites W2042647434 @default.
• W2090561982 cites W2044134083 @default.
• W2090561982 cites W2052379616 @default.
• W2090561982 cites W2052684242 @default.
• W2090561982 cites W2060707121 @default.
• W2090561982 cites W2061549038 @default.
• W2090561982 cites W2062827290 @default.
• W2090561982 cites W2062931550 @default.
• W2090561982 cites W2067891203 @default.
• W2090561982 cites W2071036994 @default.
• W2090561982 cites W2075711087 @default.
• W2090561982 cites W2076863216 @default.
• W2090561982 cites W2081162866 @default.
• W2090561982 cites W2084615605 @default.
• W2090561982 cites W2092068784 @default.
• W2090561982 cites W2093224670 @default.
• W2090561982 cites W2113683216 @default.
• W2090561982 cites W2116601874 @default.
• W2090561982 cites W2154588586 @default.
• W2090561982 cites W2173426336 @default.
• W2090561982 cites W2395167429 @default.
• W2090561982 doi "https://doi.org/10.1038/sj.bjp.0701853" @default.
• W2090561982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565408" @default.
• W2090561982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9647476" @default.
• W2090561982 hasPublicationYear "1998" @default.
• W2090561982 type Work @default.
• W2090561982 sameAs 2090561982 @default.
• W2090561982 citedByCount "90" @default.
• W2090561982 countsByYear W20905619822012 @default.
• W2090561982 countsByYear W20905619822013 @default.
• W2090561982 countsByYear W20905619822014 @default.
• W2090561982 countsByYear W20905619822015 @default.
• W2090561982 countsByYear W20905619822018 @default.
• W2090561982 countsByYear W20905619822019 @default.
• W2090561982 countsByYear W20905619822020 @default.
• W2090561982 countsByYear W20905619822021 @default.
• W2090561982 countsByYear W20905619822023 @default.
• W2090561982 crossrefType "journal-article" @default.
• W2090561982 hasAuthorship W2090561982A5026950758 @default.
• W2090561982 hasAuthorship W2090561982A5027330002 @default.
• W2090561982 hasAuthorship W2090561982A5065315705 @default.
• W2090561982 hasAuthorship W2090561982A5072070682 @default.
• W2090561982 hasAuthorship W2090561982A5078255099 @default.
• W2090561982 hasBestOaLocation W20905619822 @default.
• W2090561982 hasConcept C126322002 @default.
• W2090561982 hasConcept C134018914 @default.
• W2090561982 hasConcept C170493617 @default.
• W2090561982 hasConcept C178592051 @default.
• W2090561982 hasConcept C185592680 @default.

• next