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- W2090572893 abstract "Identification of a family affected by antithrombin-III heparin cofactor (AT-III) deficiency was made after diagnosis of the index case, a 15-year-old male, who suffered a cerebral thrombosis after a 2-year past history of thromboses in the lower extremities. The patient showed a marked resistance to heparinization after his cerebral thrombosis. The mother and the sister of the index case were also affected. Studies showed decreased biologic activity (A) and antigen by the Laurell immunologic technique (I) of AT-III in the index case (A=27%, I=47%), his sister (A=29%, I=47%), and his mother (A=40%, I=56%). The normal range (±2SD) la A=66-138% and I=79-115%. Crossed immuno-electrophoresis (CIE) in agar containing heparin of patients' plasma and recalcified plasma revealed a pattern of migration identical with normal. After anticoagulant therapy with coumarin, AT-III activity and/or antigen was increased: index case (A=45%, I=65%), his sister (A=28%, I=62%), and mother (A=79%, I=88%). CIE on plasma and serum of the affected patients on coumarin were identical in pattern to a normal control on coumarin. In this family, the levels of AT-III activity and antigen were proportionately reduced and there appeared to be no qualitative differences in the AT-III molecule on CIE. Interestingly, both the AT-III activity and antigen increased on anticoagulant therapy with coumarin." @default.
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- W2090572893 date "1977-04-01" @default.
- W2090572893 modified "2023-09-25" @default.
- W2090572893 title "ANTITHROMBIN-III HEPARIN COFACTOR DEFICIENCY IN A FAMILY: BIOLOGIC ACTIVITY, ANTIGENIC LEVELS, AND CROSSED IMMUNOELECTROPHORETIC ANALYSIS BEFORE AND AFTER THERAPY" @default.
- W2090572893 doi "https://doi.org/10.1203/00006450-197704000-00579" @default.
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