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- W2090573670 abstract "Ephexin-1 functions as guanine nucleotide exchange factors for the Rho-type GTPases which have important roles in neuronal development including axon guidance, migration, morphogenesis, and plasticity of neurons. As little is known about ephexin-1 in the cerebellum, we investigated the immunolocalization of ephexin-1 in the developing canine cerebellum. While the cellular maturation was followed by the temporal pattern, the calbindin D-28k and ephexin-1 immunoreactivities gradually increased in developing canine cerebellum. When compared to the calbindin D-28k immunoreactivities, belated ephexin-1 immunolocalization was observed in the Purkinje cells which aligned a single layer during cerebellar development. These results suggest that ephexin-1 might play an important role in the development of the Purkinje cells during the first two postnatal weeks based on its immunolocalization in the present study." @default.
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- W2090573670 date "2014-01-01" @default.
- W2090573670 modified "2023-10-01" @default.
- W2090573670 title "Immunolocalization of Ephexin-1 in the Developing Canine Cerebellum" @default.
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- W2090573670 doi "https://doi.org/10.4236/nm.2014.51002" @default.
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