FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090578576> ?p ?o ?g. }

• W2090578576 endingPage "131" @default.
• W2090578576 startingPage "123" @default.
• W2090578576 abstract "Previous studies, aimed at identifying which diffusible signals may influence the differentiation of embryonic neurons towards the monoaminergic phenotypes during brain development, have shown that serotonin itself could promote the ‘serotoninergic-like properties’ of hypothalamic cells from mouse embryos. We presently reinvestigated such ‘autocrine/paracrine’ regulatory mechanisms by exposing dissociated cell cultures from embryonic rat hypothalamus and brain stem to dopamine — or related agonists — in an attempt to influence their differentiation towards the catecholaminergic phenotype. Chronic treatment of cells by dopamine or apomorphine (a mixed D1/D2 agonist), but not selective D1 and D2 agonists, significantly increased the number of cells that expressed tyrosine hydroxylase (TH; as assessed with a specific anti-TH antiserum) and the activity of aromatic l-amino acid decarboxylase (AADC) in the cultures. Furthermore, apomorphine treatment also decreased the levels of cholecystokinin-like material in primary cultures from the brainstem (but not the hypothalamus) where both dopamine and cholecystokinin are — partly — colocalized in mesencephalic dopaminergic neurons. The maximal effects of both dopamine and apomorphine on TH expression and AADC activity occurred earlier in the brainstem (on cells from 14- to 15-day-old embryos) than in the hypothalamus (on cells from 15- to 16-day-old embryos), in line with the well established caudo-rostral maturation of the rat brain. Furthermore both the expression and the dopamine-induced modulation of AADC activity and TH immunoreactivity appeared to occur independently of each other. Present and previous data are in agreement with a possible autocrine/paracrine action of dopamine and serotonin during brain development. According to this concept, these neurotransmitters, originating from various sources in the embryo in vivo, might trigger the differentiation of some embryonic precursor cells towards catecholaminergic or serotonergic neurons by acting through specific receptors." @default.
• W2090578576 created "2016-06-24" @default.
• W2090578576 creator A5000891914 @default.
• W2090578576 creator A5038507730 @default.
• W2090578576 creator A5073247947 @default.
• W2090578576 creator A5074081331 @default.
• W2090578576 creator A5085992521 @default.
• W2090578576 creator A5090410878 @default.
• W2090578576 date "1991-04-01" @default.
• W2090578576 modified "2023-10-18" @default.
• W2090578576 title "Dopamine increases the expression of tyrosine hydroxylase and aromatic amino acid decarboxylase in primary cultures of fetal neurons" @default.
• W2090578576 cites W1546189385 @default.
• W2090578576 cites W1740137726 @default.
• W2090578576 cites W1862144680 @default.
• W2090578576 cites W1964705865 @default.
• W2090578576 cites W1968799745 @default.
• W2090578576 cites W1981818755 @default.
• W2090578576 cites W2001220158 @default.
• W2090578576 cites W2006053680 @default.
• W2090578576 cites W2009205613 @default.
• W2090578576 cites W2015694781 @default.
• W2090578576 cites W2016302775 @default.
• W2090578576 cites W2016411315 @default.
• W2090578576 cites W2018445261 @default.
• W2090578576 cites W2024927923 @default.
• W2090578576 cites W2026631379 @default.
• W2090578576 cites W2030905853 @default.
• W2090578576 cites W2033412830 @default.
• W2090578576 cites W2034408205 @default.
• W2090578576 cites W2040716512 @default.
• W2090578576 cites W2041607843 @default.
• W2090578576 cites W2044779961 @default.
• W2090578576 cites W2051414078 @default.
• W2090578576 cites W2053525883 @default.
• W2090578576 cites W2054611691 @default.
• W2090578576 cites W2056955251 @default.
• W2090578576 cites W2071231226 @default.
• W2090578576 cites W2077108130 @default.
• W2090578576 cites W2079265354 @default.
• W2090578576 cites W2091723337 @default.
• W2090578576 cites W2091840632 @default.
• W2090578576 cites W2127939929 @default.
• W2090578576 cites W2133267068 @default.
• W2090578576 cites W2170714458 @default.
• W2090578576 cites W2174825349 @default.
• W2090578576 cites W2511867458 @default.
• W2090578576 cites W4241399060 @default.
• W2090578576 cites W4247067925 @default.
• W2090578576 doi "https://doi.org/10.1016/0165-3806(91)90092-w" @default.
• W2090578576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1680579" @default.
• W2090578576 hasPublicationYear "1991" @default.
• W2090578576 type Work @default.
• W2090578576 sameAs 2090578576 @default.
• W2090578576 citedByCount "36" @default.
• W2090578576 crossrefType "journal-article" @default.
• W2090578576 hasAuthorship W2090578576A5000891914 @default.
• W2090578576 hasAuthorship W2090578576A5038507730 @default.
• W2090578576 hasAuthorship W2090578576A5073247947 @default.
• W2090578576 hasAuthorship W2090578576A5074081331 @default.
• W2090578576 hasAuthorship W2090578576A5085992521 @default.
• W2090578576 hasAuthorship W2090578576A5090410878 @default.
• W2090578576 hasConcept C126322002 @default.
• W2090578576 hasConcept C134018914 @default.
• W2090578576 hasConcept C137183658 @default.
• W2090578576 hasConcept C159167319 @default.
• W2090578576 hasConcept C170493617 @default.
• W2090578576 hasConcept C2775864247 @default.
• W2090578576 hasConcept C2775951788 @default.
• W2090578576 hasConcept C2776219046 @default.
• W2090578576 hasConcept C2776824294 @default.
• W2090578576 hasConcept C2777003273 @default.
• W2090578576 hasConcept C2777525119 @default.
• W2090578576 hasConcept C37000724 @default.
• W2090578576 hasConcept C513476851 @default.
• W2090578576 hasConcept C529278444 @default.
• W2090578576 hasConcept C55493867 @default.
• W2090578576 hasConcept C58824617 @default.
• W2090578576 hasConcept C71924100 @default.
• W2090578576 hasConcept C86803240 @default.
• W2090578576 hasConceptScore W2090578576C126322002 @default.
• W2090578576 hasConceptScore W2090578576C134018914 @default.
• W2090578576 hasConceptScore W2090578576C137183658 @default.
• W2090578576 hasConceptScore W2090578576C159167319 @default.
• W2090578576 hasConceptScore W2090578576C170493617 @default.
• W2090578576 hasConceptScore W2090578576C2775864247 @default.
• W2090578576 hasConceptScore W2090578576C2775951788 @default.
• W2090578576 hasConceptScore W2090578576C2776219046 @default.
• W2090578576 hasConceptScore W2090578576C2776824294 @default.
• W2090578576 hasConceptScore W2090578576C2777003273 @default.
• W2090578576 hasConceptScore W2090578576C2777525119 @default.
• W2090578576 hasConceptScore W2090578576C37000724 @default.
• W2090578576 hasConceptScore W2090578576C513476851 @default.
• W2090578576 hasConceptScore W2090578576C529278444 @default.
• W2090578576 hasConceptScore W2090578576C55493867 @default.
• W2090578576 hasConceptScore W2090578576C58824617 @default.
• W2090578576 hasConceptScore W2090578576C71924100 @default.
• W2090578576 hasConceptScore W2090578576C86803240 @default.
• W2090578576 hasIssue "2" @default.

• next