Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090592798> ?p ?o ?g. }
- W2090592798 endingPage "294" @default.
- W2090592798 startingPage "285" @default.
- W2090592798 abstract "Dysfunction of neurotrophic mechanisms represents an important possible cause of neurodegeneration. Basal forebrain cholinergic neurons provide a useful model system in which to investigate this possibility since these neurons atrophy and degenerate in aging and Alzheimer's disease, and bear receptors to the neurotrophins NGF and BDNF. Neuropathologic evidence to date suggests that production of neurotrophins is not substantially decreased in aging or Alzheimer's disease, and experimental studies show that decreased access to targetderived neurotrophin may cause neuronal atrophy but is not lethal to mature basal forebrain cholinergic neurons. In aged rats, basal forebrain cholinergic neurons show a substantial decline in their capacity to take up and retrogradely transport 125 I-labelled NGF from their target region, and neurons not transporting labelled NGF appear severely atrophic. These changes are accompanied by a pronounced reduction in basal forebrain levels of mRNA encoding the high affinity NGF receptor. Together these findings suggest that while reduced levels of target-derived neurotrophin may not be a major factor in causing neuronal cell death they may contribute to atrophic neurodegenerative changes. In addition, intrinsic changes such as an age-related reduction in the capacity to sustain receptor mediated uptake and retrograde transport of target-derived neurotrophins may render certain neurons more vulnerable to neurodegeneration." @default.
- W2090592798 created "2016-06-24" @default.
- W2090592798 creator A5004141688 @default.
- W2090592798 creator A5011858801 @default.
- W2090592798 date "1993-08-01" @default.
- W2090592798 modified "2023-09-23" @default.
- W2090592798 title "Neurotrophic mechanisms and neuronal degeneration" @default.
- W2090592798 cites W142080826 @default.
- W2090592798 cites W1483078453 @default.
- W2090592798 cites W1609471181 @default.
- W2090592798 cites W1639832183 @default.
- W2090592798 cites W1820424262 @default.
- W2090592798 cites W1917781517 @default.
- W2090592798 cites W1927096988 @default.
- W2090592798 cites W1966019489 @default.
- W2090592798 cites W1969099021 @default.
- W2090592798 cites W1978817724 @default.
- W2090592798 cites W1979101609 @default.
- W2090592798 cites W1984907449 @default.
- W2090592798 cites W1988791308 @default.
- W2090592798 cites W1991251623 @default.
- W2090592798 cites W1991510232 @default.
- W2090592798 cites W1994852189 @default.
- W2090592798 cites W1997053715 @default.
- W2090592798 cites W1998925703 @default.
- W2090592798 cites W2004045063 @default.
- W2090592798 cites W2005780620 @default.
- W2090592798 cites W2007826751 @default.
- W2090592798 cites W2009173102 @default.
- W2090592798 cites W2010936735 @default.
- W2090592798 cites W2013305718 @default.
- W2090592798 cites W2014484683 @default.
- W2090592798 cites W2016053122 @default.
- W2090592798 cites W2017046563 @default.
- W2090592798 cites W2017681525 @default.
- W2090592798 cites W2018033757 @default.
- W2090592798 cites W2018911801 @default.
- W2090592798 cites W2019961134 @default.
- W2090592798 cites W2021092333 @default.
- W2090592798 cites W2021097827 @default.
- W2090592798 cites W2022951192 @default.
- W2090592798 cites W2023142792 @default.
- W2090592798 cites W2023664289 @default.
- W2090592798 cites W2025226185 @default.
- W2090592798 cites W2025543844 @default.
- W2090592798 cites W2026624422 @default.
- W2090592798 cites W2027988197 @default.
- W2090592798 cites W2033603470 @default.
- W2090592798 cites W2034258686 @default.
- W2090592798 cites W2034783116 @default.
- W2090592798 cites W2035339855 @default.
- W2090592798 cites W2036288989 @default.
- W2090592798 cites W2037194302 @default.
- W2090592798 cites W2039943037 @default.
- W2090592798 cites W2040983591 @default.
- W2090592798 cites W2043421056 @default.
- W2090592798 cites W2046003759 @default.
- W2090592798 cites W2046739492 @default.
- W2090592798 cites W2048643640 @default.
- W2090592798 cites W2050838682 @default.
- W2090592798 cites W2055979394 @default.
- W2090592798 cites W2056941695 @default.
- W2090592798 cites W2057377575 @default.
- W2090592798 cites W2057415339 @default.
- W2090592798 cites W2060907356 @default.
- W2090592798 cites W2064630391 @default.
- W2090592798 cites W2064659680 @default.
- W2090592798 cites W2069095254 @default.
- W2090592798 cites W2072229950 @default.
- W2090592798 cites W2074514790 @default.
- W2090592798 cites W2075535415 @default.
- W2090592798 cites W2076193941 @default.
- W2090592798 cites W2076433885 @default.
- W2090592798 cites W2076835610 @default.
- W2090592798 cites W2084076460 @default.
- W2090592798 cites W2086173436 @default.
- W2090592798 cites W2087607782 @default.
- W2090592798 cites W2092139968 @default.
- W2090592798 cites W2093374391 @default.
- W2090592798 cites W2094220775 @default.
- W2090592798 cites W2121790796 @default.
- W2090592798 cites W2081246312 @default.
- W2090592798 doi "https://doi.org/10.1016/s1044-5765(05)80034-x" @default.
- W2090592798 hasPublicationYear "1993" @default.
- W2090592798 type Work @default.
- W2090592798 sameAs 2090592798 @default.
- W2090592798 citedByCount "20" @default.
- W2090592798 countsByYear W20905927982014 @default.
- W2090592798 countsByYear W20905927982015 @default.
- W2090592798 crossrefType "journal-article" @default.
- W2090592798 hasAuthorship W2090592798A5004141688 @default.
- W2090592798 hasAuthorship W2090592798A5011858801 @default.
- W2090592798 hasConcept C126322002 @default.
- W2090592798 hasConcept C142724271 @default.
- W2090592798 hasConcept C15744967 @default.
- W2090592798 hasConcept C160539049 @default.
- W2090592798 hasConcept C169760540 @default.
- W2090592798 hasConcept C170493617 @default.