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• W2090594927 startingPage "12811" @default.
• W2090594927 abstract "Significance It is unknown how (or if) the chromatin landscape responds to transcription stalling to signal rescue of arrested RNA polymerase II (RNAPII). This study identifies a chromatin response to DNA damage-induced RNAPII arrest, the rapid deubiquitylation of histone H2B. This response is an important step for fine-tuning the chromatin landscape to allow the occurrence of DNA repair while avoiding excess RNAPII degradation. Our finding sheds light on the rescue of stalled RNAPII in the context of chromatin, illuminating the involvement of H2B deubiquitylation in coordinating different rescue pathways. Importantly, defects in RNAPII rescue are a phenotype of the human disease Cockayne syndrome, which is characterized by photosensitivity, neurological degeneration, and premature aging." @default.
• W2090594927 created "2016-06-24" @default.
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• W2090594927 creator A5080261955 @default.
• W2090594927 date "2014-08-18" @default.
• W2090594927 modified "2023-10-16" @default.
• W2090594927 title "UV damage-induced RNA polymerase II stalling stimulates H2B deubiquitylation" @default.
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• W2090594927 doi "https://doi.org/10.1073/pnas.1403901111" @default.
• W2090594927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4156752" @default.
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• W2090594927 hasPublicationYear "2014" @default.
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