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- W2090596170 abstract "The analysis of genomic alterations in acute lymphoblastic leukemia (ALL) has provided new insights for prognosis and possible targets of novel therapies. In T-ALL the role of molecular abnormalities has still to be determined. Deregulated promoter hypermethylation of critical genes like PAX5 may have a significant impact on the course of ALL. Samples derived from 75 patients with ALL (B-ALL = 24, T-ALL = 51) and from healthy volunteers were analyzed. PAX5 expression was assessed by micro-array analysis (HG-U133plus 2.0) and correlated with promoter CpG island methylation of PAX5 using a pyrosequencing approach. The analyzed CpG marks in the promoter region of PAX5 were completely and uniformly unmethylated in the control group of healthy individuals. The T-ALL cases featured even higher methylation levels (median: 20%) with a strong variation of values of up to 85% methylation. Analysis of the association of altered methylation levels with gene expression data indicated a differential epigenetic regulation of PAX5 through promoter methylation which may contribute to the pathogenesis of this disease." @default.
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- W2090596170 date "2011-05-01" @default.
- W2090596170 modified "2023-10-02" @default.
- W2090596170 title "Epigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia" @default.
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- W2090596170 doi "https://doi.org/10.1016/j.leukres.2010.11.015" @default.
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