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• W2090610111 abstract "Long-term treatment of rats with haloperidol produced an increased sensitivity to the locomotor and stereotypic effect of apomorphine. This behavioral dopaminergic supersensitivity was accompanied by increased binding of [3H] spiroperidol in the striatum. Rats treated concurrently with lithium and haloperidol failed to develop both behavioral sensitivity to apomorphine and increased striatal dopamine receptor binding. The ability of lighium to prevent recurrent manicdepressive episodes may be related, in part, to its ability to stabilize dopaminergic receptor sensitivity." @default.
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• W2090610111 date "1978-07-14" @default.
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• W2090610111 title "Long-Term Treatment with Lithium Prevents the Development of Dopamine Receptor Supersensitivity" @default.
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• W2090610111 doi "https://doi.org/10.1126/science.566468" @default.
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