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• W2090615019 abstract "Chondrocytes propagated in monolayer culture proliferate and change into ‘fibroblastoid’-like cells. This change is characterized by a shift in production of collagen type II to I and from high- to low-molecular-weight proteoglycans. When propagated in three-dimensional culture, chondrocytes have limited ability to divide but re-express their original characteristics. The goal of the present study was to determine whether a microcarrier suspension culture system would support chondrocyte proliferation and phenotype expression. Our experiments indicate that a collagen type I microcarrier (cellagen) best supported chondrocyte proliferation and phenotype expression. Cells in cellagen microcarriers multiplied at least twentyfold within 2 weeks and had doubling times of 2 to 3 d. Viable and metabolically active cells were retrieved with ease. The harvested chondrocytes had no detectable staining for collagen type I and stained intensely for collagen type II. Our studies demonstrate that the microcarrier suspension culture system supports growth and enhances expression of the ‘chondrocytic’ phenotype. Attachment to a constrained surface and the fluid shear forces on the microcarriers during suspension culture may have helped chondrocytes to reacquire their rounded shape and produce cartilage matrix components." @default.
• W2090615019 created "2016-06-24" @default.
• W2090615019 creator A5034926326 @default.
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• W2090615019 date "1996-01-01" @default.
• W2090615019 modified "2023-10-03" @default.
• W2090615019 title "Human chondrocytes proliferate and produce matrix components in microcarrier suspension culture" @default.
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• W2090615019 doi "https://doi.org/10.1016/0142-9612(96)83283-2" @default.
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