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• W2090618446 endingPage "2491" @default.
• W2090618446 startingPage "2486" @default.
• W2090618446 abstract "An intra-S phase checkpoint slows the rate of DNA replication in response to DNA damage and replication fork blocks in eukaryotic cells. In the budding yeast Saccharomyces cerevisiae, such down-regulation is achieved through the Rad53 kinase-dependent block of origins of replication. We have identified the Rad53 phosphorylation sites on Dbf4, the activator subunit of the essential S phase Dbf4-dependent kinase, and generated a non-phosphorylatable Dbf4 mutant (dbf4(7A)). We show here that dbf4(7A) is a bona fide intra-S phase checkpoint bypass allele that contributes to abrogating the Rad53 block of origin firing in response to genotoxic stress." @default.
• W2090618446 created "2016-06-24" @default.
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• W2090618446 date "2011-01-01" @default.
• W2090618446 modified "2023-09-28" @default.
• W2090618446 title "A Dbf4 Mutant Contributes to Bypassing the Rad53-mediated Block of Origins of Replication in Response to Genotoxic Stress" @default.
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• W2090618446 doi "https://doi.org/10.1074/jbc.m110.190843" @default.
• W2090618446 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3024743" @default.
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• W2090618446 hasPublicationYear "2011" @default.
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