FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090621408> ?p ?o ?g. }

• W2090621408 endingPage "696" @default.
• W2090621408 startingPage "675" @default.
• W2090621408 abstract "Lymphocytes express most of the cholinergic components found in the nervous system, including acetylcholine (ACh), choline acetyltransferase (ChAT), high affinity choline transporter, muscarinic and nicotinic ACh receptors (mAChRs and nAChRs, respectively), and acetylcholinesterase. Stimulation of T and B cells with ACh or another mAChR agonist elicits intracellular Ca2+ signaling, up-regulation of c-fos expression, increased nitric oxide synthesis and IL-2-induced signal transduction, probably via M3 and M5 mAChR-mediated pathways. Acute stimulation of nAChRs with ACh or nicotine causes rapid and transient Ca2+ signaling in T and B cells, probably via alpha7 nAChR subunit-mediated pathways. Chronic nicotine stimulation, by contrast, down-regulates nAChR expression and suppresses T cell activity. Activation of T cells with phytohemagglutinin or antibodies against cell surface molecules enhances lymphocytic cholinergic transmission by activating expression of ChAT and M5 mAChR, which is suggestive of local cholinergic regulation of immune system activity. This idea is supported by the facts that lymphocytic cholinergic activity reflects well the changes in immune system function seen in animal models of immune deficiency and immune acceleration. Collectively, these data provide a compelling picture in which lymphocytes constitute a cholinergic system that is independent of cholinergic nerves, and which is involved in the regulation of immune function." @default.
• W2090621408 created "2016-06-24" @default.
• W2090621408 creator A5017848730 @default.
• W2090621408 creator A5063361747 @default.
• W2090621408 date "2003-12-01" @default.
• W2090621408 modified "2023-09-23" @default.
• W2090621408 title "The lymphocytic cholinergic system and its contribution to the regulation of immune activity" @default.
• W2090621408 cites W106040142 @default.
• W2090621408 cites W1522182888 @default.
• W2090621408 cites W1964581596 @default.
• W2090621408 cites W1973531583 @default.
• W2090621408 cites W1976426993 @default.
• W2090621408 cites W1980857453 @default.
• W2090621408 cites W1981986455 @default.
• W2090621408 cites W1983330051 @default.
• W2090621408 cites W1986393728 @default.
• W2090621408 cites W1991141101 @default.
• W2090621408 cites W1991481058 @default.
• W2090621408 cites W1991618197 @default.
• W2090621408 cites W1993388601 @default.
• W2090621408 cites W1995525413 @default.
• W2090621408 cites W1996935852 @default.
• W2090621408 cites W2001036657 @default.
• W2090621408 cites W2003848307 @default.
• W2090621408 cites W2005941115 @default.
• W2090621408 cites W2006162273 @default.
• W2090621408 cites W2006537366 @default.
• W2090621408 cites W2008839292 @default.
• W2090621408 cites W2010218875 @default.
• W2090621408 cites W2011336280 @default.
• W2090621408 cites W2012851391 @default.
• W2090621408 cites W2014474215 @default.
• W2090621408 cites W2016498619 @default.
• W2090621408 cites W2019743128 @default.
• W2090621408 cites W2021141031 @default.
• W2090621408 cites W2023197593 @default.
• W2090621408 cites W2023542089 @default.
• W2090621408 cites W2027337530 @default.
• W2090621408 cites W2028033611 @default.
• W2090621408 cites W2039285377 @default.
• W2090621408 cites W2041507634 @default.
• W2090621408 cites W2045324164 @default.
• W2090621408 cites W2045971025 @default.
• W2090621408 cites W2048606015 @default.
• W2090621408 cites W2051576079 @default.
• W2090621408 cites W2052282182 @default.
• W2090621408 cites W2052845314 @default.
• W2090621408 cites W2053383171 @default.
• W2090621408 cites W2053738569 @default.
• W2090621408 cites W2054755999 @default.
• W2090621408 cites W2058494498 @default.
• W2090621408 cites W2058878434 @default.
• W2090621408 cites W2058912903 @default.
• W2090621408 cites W2060767911 @default.
• W2090621408 cites W2060942917 @default.
• W2090621408 cites W2062330428 @default.
• W2090621408 cites W2063270148 @default.
• W2090621408 cites W2064163333 @default.
• W2090621408 cites W2065368156 @default.
• W2090621408 cites W2066085139 @default.
• W2090621408 cites W2066926642 @default.
• W2090621408 cites W2069368135 @default.
• W2090621408 cites W2072791272 @default.
• W2090621408 cites W2072812401 @default.
• W2090621408 cites W2073716330 @default.
• W2090621408 cites W2074024704 @default.
• W2090621408 cites W2074582788 @default.
• W2090621408 cites W2074920577 @default.
• W2090621408 cites W2075191516 @default.
• W2090621408 cites W2084286451 @default.
• W2090621408 cites W2084308158 @default.
• W2090621408 cites W2084384082 @default.
• W2090621408 cites W2086451909 @default.
• W2090621408 cites W2092439492 @default.
• W2090621408 cites W2093712515 @default.
• W2090621408 cites W2094760990 @default.
• W2090621408 cites W2100402872 @default.
• W2090621408 cites W2108055703 @default.
• W2090621408 cites W2111359173 @default.
• W2090621408 cites W2114973916 @default.
• W2090621408 cites W2156595997 @default.
• W2090621408 cites W2158410030 @default.
• W2090621408 cites W2163252583 @default.
• W2090621408 cites W2270700935 @default.
• W2090621408 cites W2338977280 @default.
• W2090621408 cites W2586372093 @default.
• W2090621408 cites W3101145904 @default.
• W2090621408 cites W3101964718 @default.
• W2090621408 cites W3105540174 @default.
• W2090621408 cites W3168413161 @default.
• W2090621408 cites W361598898 @default.
• W2090621408 cites W2066935426 @default.
• W2090621408 doi "https://doi.org/10.1016/j.lfs.2003.09.037" @default.
• W2090621408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14654162" @default.
• W2090621408 hasPublicationYear "2003" @default.
• W2090621408 type Work @default.
• W2090621408 sameAs 2090621408 @default.
• W2090621408 citedByCount "293" @default.

• next