FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090628304> ?p ?o ?g. }

• W2090628304 abstract "New drugs are generally claimed to represent a therapeutic innovation. However, scientific evidence of a substantial clinical advantage is often lacking. This may be the result of using inadequate control groups or surrogate outcomes only in the clinical trials. In view of this, EVITA was developed as a user-friendly transparent tool for the early evaluation of the additional therapeutic value of a new drug.EVITA does not evaluate a new compound per se but in an approved indication in comparison with existing therapeutic strategies. Placebo as a comparator is accepted only in the absence of an established therapy or if employed in an add-on strategy on top. The evaluation attributes rating points to the drug in question, taking into consideration both therapeutic benefit and risk profile. The compound scores positive points for superiority in efficiency and/or adverse effects as demonstrated in randomized controlled trials (RCTs), whilst negative points are awarded for inferiority and/or an unfavorable risk profile. The evaluation follows an algorithm considering the clinical relevance of the outcomes, the strength of the therapeutic effect and the number of RCTs performed. Categories for therapeutic aim and disease severity, although essential parts of the EVITA assessment, are attributed but do not influence the EVITA score which is presented as a color-coded bar graph. In case the available data were unsuitable for an EVITA calculation, a traffic-type yield sign is assigned instead to criticize such practice. The results are presented online http://www.evita-report.de together with all RCTs considered as well as the reasons for excluding a given RCT from the evaluation. This allows for immediate revision in response to justified criticism and simplifies the inclusion of new data.As examples, four compounds which received approval within the last years were evaluated for one of their clinical indications: lenalidomide, pioglitazone, bupropion and zoledronic acid. Only the first achieved an EVITA score above zero indicating therapeutic advantage.The strength of EVITA appears to lie in its speedy assessment of the potential therapeutic advantage of a new drug for a given indication. At the same time, this approach draws attention to the typical deficits of data used for drug approval. EVITA is not intended to replace classical health technology assessment reports but rather serves as a screening tool in the sense of horizon scanning." @default.
• W2090628304 created "2016-06-24" @default.
• W2090628304 creator A5001508681 @default.
• W2090628304 creator A5009429677 @default.
• W2090628304 creator A5009642804 @default.
• W2090628304 creator A5059674669 @default.
• W2090628304 creator A5076948214 @default.
• W2090628304 date "2010-03-16" @default.
• W2090628304 modified "2023-10-16" @default.
• W2090628304 title "EVITA: a tool for the early EValuation of pharmaceutical Innovations with regard to Therapeutic Advantage" @default.
• W2090628304 cites W1480729244 @default.
• W2090628304 cites W1566733175 @default.
• W2090628304 cites W1586699954 @default.
• W2090628304 cites W1969102243 @default.
• W2090628304 cites W1978228601 @default.
• W2090628304 cites W1986215651 @default.
• W2090628304 cites W1992538067 @default.
• W2090628304 cites W1993035292 @default.
• W2090628304 cites W2003635400 @default.
• W2090628304 cites W2009499605 @default.
• W2090628304 cites W2018434620 @default.
• W2090628304 cites W2021954218 @default.
• W2090628304 cites W2023447984 @default.
• W2090628304 cites W2023888444 @default.
• W2090628304 cites W2028038659 @default.
• W2090628304 cites W2036764488 @default.
• W2090628304 cites W2038693293 @default.
• W2090628304 cites W2047397850 @default.
• W2090628304 cites W2121822533 @default.
• W2090628304 cites W2149634568 @default.
• W2090628304 cites W2159969745 @default.
• W2090628304 doi "https://doi.org/10.1186/1472-6904-10-5" @default.
• W2090628304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2858124" @default.
• W2090628304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20233429" @default.
• W2090628304 hasPublicationYear "2010" @default.
• W2090628304 type Work @default.
• W2090628304 sameAs 2090628304 @default.
• W2090628304 citedByCount "12" @default.
• W2090628304 countsByYear W20906283042012 @default.
• W2090628304 countsByYear W20906283042013 @default.
• W2090628304 countsByYear W20906283042014 @default.
• W2090628304 countsByYear W20906283042016 @default.
• W2090628304 countsByYear W20906283042018 @default.
• W2090628304 countsByYear W20906283042019 @default.
• W2090628304 countsByYear W20906283042020 @default.
• W2090628304 countsByYear W20906283042021 @default.
• W2090628304 crossrefType "journal-article" @default.
• W2090628304 hasAuthorship W2090628304A5001508681 @default.
• W2090628304 hasAuthorship W2090628304A5009429677 @default.
• W2090628304 hasAuthorship W2090628304A5009642804 @default.
• W2090628304 hasAuthorship W2090628304A5059674669 @default.
• W2090628304 hasAuthorship W2090628304A5076948214 @default.
• W2090628304 hasBestOaLocation W20906283041 @default.
• W2090628304 hasConcept C126322002 @default.
• W2090628304 hasConcept C142724271 @default.
• W2090628304 hasConcept C168563851 @default.
• W2090628304 hasConcept C177713679 @default.
• W2090628304 hasConcept C204787440 @default.
• W2090628304 hasConcept C27081682 @default.
• W2090628304 hasConcept C535046627 @default.
• W2090628304 hasConcept C71924100 @default.
• W2090628304 hasConceptScore W2090628304C126322002 @default.
• W2090628304 hasConceptScore W2090628304C142724271 @default.
• W2090628304 hasConceptScore W2090628304C168563851 @default.
• W2090628304 hasConceptScore W2090628304C177713679 @default.
• W2090628304 hasConceptScore W2090628304C204787440 @default.
• W2090628304 hasConceptScore W2090628304C27081682 @default.
• W2090628304 hasConceptScore W2090628304C535046627 @default.
• W2090628304 hasConceptScore W2090628304C71924100 @default.
• W2090628304 hasIssue "1" @default.
• W2090628304 hasLocation W20906283041 @default.
• W2090628304 hasLocation W20906283042 @default.
• W2090628304 hasLocation W20906283043 @default.
• W2090628304 hasLocation W20906283044 @default.
• W2090628304 hasOpenAccess W2090628304 @default.
• W2090628304 hasPrimaryLocation W20906283041 @default.
• W2090628304 hasRelatedWork W2052539084 @default.
• W2090628304 hasRelatedWork W2235574018 @default.
• W2090628304 hasRelatedWork W2507295142 @default.
• W2090628304 hasRelatedWork W2953633878 @default.
• W2090628304 hasRelatedWork W3159250744 @default.
• W2090628304 hasRelatedWork W3195440323 @default.
• W2090628304 hasRelatedWork W4233016836 @default.
• W2090628304 hasRelatedWork W4256514411 @default.
• W2090628304 hasRelatedWork W4292236216 @default.
• W2090628304 hasRelatedWork W2083697902 @default.
• W2090628304 hasVolume "10" @default.
• W2090628304 isParatext "false" @default.
• W2090628304 isRetracted "false" @default.
• W2090628304 magId "2090628304" @default.
• W2090628304 workType "article" @default.