FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090630871> ?p ?o ?g. }

• W2090630871 endingPage "319" @default.
• W2090630871 startingPage "309" @default.
• W2090630871 abstract "The effects of long chain n-3 polyunsaturated fatty acids (PUFA) on the desaturation and elongation systems involved in the conversion of 18:3n-3 to 24:6n-3 were investigated. Microsomes were prepared from the livers of rainbow trout and incubated with 14C-labelled 18:3n-3 and cofactors required for elongation and/or desaturation in the presence of 22:6n-3, 24:5n-3 or 24:6n-3. The formation of 24:6n-3 was significantly inhibited in the presence of 50 μM 22:6n-3, 24:5n-3 or 24:6n-3, whereas the amount of radiolabelled 20:5n-3 formed was inhibited by only 24:5n-3 or 24:6n-3 at the same concentration. When malonyl-CoA was omitted from the incubation system to allow the measurement of desaturation in the absence of elongation, the Δ6 desaturation of 14C-18:3n-3 to 14C-18:4n-3 was inhibited by approximately 25% in the presence of 24:5n-3 or 24:6n-3 but was not affected by 22:6n-3. The Δ5 desaturation of 14C-20:4n-3 was not affected by the presence of any of the long chain PUFA and no significant effect of 18:3n-3, 22:6n-3 or 24:6n-3 on the Δ6 desaturation of 24:5n-3 to 24:6n-3 was observed. To permit the measurement of individual elongation reactions, KCN was included in the incubation medium to inhibit desaturation and 14C-labelled 18:3n-3, 18:4n-3, 20:4n-3, 20:5n-3 and 22:5n-3 were examined as substrates. 18:4n-3 and 22:5n-3 were more extensively used for elongation than 18:3n-3, 20:4n-3 and 20:5n-3. The presence of 22:6n-3, 24:5n-3 or 24:6n-3 in the incubation system had no effect on any of the specific elongations of any of the substrates examined. It is concluded that, in the conversion of 18:3n-3 to 24:6n-3 by trout liver microsomes, the Δ6 desaturation of 18:3n-3 may be subjected to direct feedback inhibition and that 24:5n-3 may be preferred over 18:3n-3 as a substrate for Δ6 desaturation." @default.
• W2090630871 created "2016-06-24" @default.
• W2090630871 creator A5006413907 @default.
• W2090630871 creator A5023290505 @default.
• W2090630871 creator A5074316481 @default.
• W2090630871 creator A5074834581 @default.
• W2090630871 date "1998-06-01" @default.
• W2090630871 modified "2023-09-30" @default.
• W2090630871 title "Effects of docosahexaenoic (22:6n-3), tetracosapentaenoic (24:5n-3) and tetracosahexaenoic (24:6n-3) acids on the desaturation and elongation of n-3 polyunsaturated fatty acids in trout liver microsomes" @default.
• W2090630871 cites W123093633 @default.
• W2090630871 cites W1775749144 @default.
• W2090630871 cites W1976216957 @default.
• W2090630871 cites W1985798756 @default.
• W2090630871 cites W1989133249 @default.
• W2090630871 cites W1997228449 @default.
• W2090630871 cites W1998602935 @default.
• W2090630871 cites W2013344341 @default.
• W2090630871 cites W2021486075 @default.
• W2090630871 cites W2024094247 @default.
• W2090630871 cites W2042701350 @default.
• W2090630871 cites W2061496018 @default.
• W2090630871 cites W2061857734 @default.
• W2090630871 cites W2073012362 @default.
• W2090630871 cites W2073286902 @default.
• W2090630871 cites W2073729699 @default.
• W2090630871 cites W2075915084 @default.
• W2090630871 cites W2082374938 @default.
• W2090630871 cites W2121048884 @default.
• W2090630871 cites W2169651469 @default.
• W2090630871 cites W2186476960 @default.
• W2090630871 cites W2485778398 @default.
• W2090630871 doi "https://doi.org/10.1016/s0005-2760(98)00045-9" @default.
• W2090630871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9630696" @default.
• W2090630871 hasPublicationYear "1998" @default.
• W2090630871 type Work @default.
• W2090630871 sameAs 2090630871 @default.
• W2090630871 citedByCount "7" @default.
• W2090630871 countsByYear W20906308712012 @default.
• W2090630871 countsByYear W20906308712014 @default.
• W2090630871 countsByYear W20906308712023 @default.
• W2090630871 crossrefType "journal-article" @default.
• W2090630871 hasAuthorship W2090630871A5006413907 @default.
• W2090630871 hasAuthorship W2090630871A5023290505 @default.
• W2090630871 hasAuthorship W2090630871A5074316481 @default.
• W2090630871 hasAuthorship W2090630871A5074834581 @default.
• W2090630871 hasConcept C112950240 @default.
• W2090630871 hasConcept C185592680 @default.
• W2090630871 hasConcept C19038510 @default.
• W2090630871 hasConcept C191897082 @default.
• W2090630871 hasConcept C192562407 @default.
• W2090630871 hasConcept C202751555 @default.
• W2090630871 hasConcept C25642318 @default.
• W2090630871 hasConcept C2777171753 @default.
• W2090630871 hasConcept C2779363728 @default.
• W2090630871 hasConcept C2779364145 @default.
• W2090630871 hasConcept C2909208804 @default.
• W2090630871 hasConcept C33947775 @default.
• W2090630871 hasConcept C505870484 @default.
• W2090630871 hasConcept C543025807 @default.
• W2090630871 hasConcept C55493867 @default.
• W2090630871 hasConcept C62231903 @default.
• W2090630871 hasConcept C82714985 @default.
• W2090630871 hasConcept C86803240 @default.
• W2090630871 hasConcept C87644729 @default.
• W2090630871 hasConceptScore W2090630871C112950240 @default.
• W2090630871 hasConceptScore W2090630871C185592680 @default.
• W2090630871 hasConceptScore W2090630871C19038510 @default.
• W2090630871 hasConceptScore W2090630871C191897082 @default.
• W2090630871 hasConceptScore W2090630871C192562407 @default.
• W2090630871 hasConceptScore W2090630871C202751555 @default.
• W2090630871 hasConceptScore W2090630871C25642318 @default.
• W2090630871 hasConceptScore W2090630871C2777171753 @default.
• W2090630871 hasConceptScore W2090630871C2779363728 @default.
• W2090630871 hasConceptScore W2090630871C2779364145 @default.
• W2090630871 hasConceptScore W2090630871C2909208804 @default.
• W2090630871 hasConceptScore W2090630871C33947775 @default.
• W2090630871 hasConceptScore W2090630871C505870484 @default.
• W2090630871 hasConceptScore W2090630871C543025807 @default.
• W2090630871 hasConceptScore W2090630871C55493867 @default.
• W2090630871 hasConceptScore W2090630871C62231903 @default.
• W2090630871 hasConceptScore W2090630871C82714985 @default.
• W2090630871 hasConceptScore W2090630871C86803240 @default.
• W2090630871 hasConceptScore W2090630871C87644729 @default.
• W2090630871 hasIssue "2-3" @default.
• W2090630871 hasLocation W20906308711 @default.
• W2090630871 hasLocation W20906308712 @default.
• W2090630871 hasOpenAccess W2090630871 @default.
• W2090630871 hasPrimaryLocation W20906308711 @default.
• W2090630871 hasRelatedWork W130996601 @default.
• W2090630871 hasRelatedWork W1986450487 @default.
• W2090630871 hasRelatedWork W1990371269 @default.
• W2090630871 hasRelatedWork W1994494562 @default.
• W2090630871 hasRelatedWork W2013344341 @default.
• W2090630871 hasRelatedWork W2028678001 @default.
• W2090630871 hasRelatedWork W2029427615 @default.
• W2090630871 hasRelatedWork W2074111273 @default.
• W2090630871 hasRelatedWork W3027083723 @default.
• W2090630871 hasRelatedWork W74982965 @default.

• next