Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090631820> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2090631820 endingPage "122" @default.
- W2090631820 startingPage "111" @default.
- W2090631820 abstract "Endotoxin, a potent stimulator of the immune system and an important mediator in the pathophysiology of septic shock, has been shown to alter the release of certain hormones following its systemic administration. The purpose of this study was to determine the effects of endotoxin on pituitary hormone secretion both in vivo and in vitro in sheep, with emphasis placed on its effects on growth hormone (GH) release. Endotoxin (400 ng/kg i.v.) increased plasma GH, adrenocorticotropic hormone (ACTH), cortisol and prolactin, while it decreased luteinizing hormone (LH) pulse frequency (p < 0.05). Plasma levels of tumor necrosis factor, a major mediator of endotoxin effects, also increased following endotoxin administration. Endotoxin did not affect the GH response to human GH-releasing hormone. In vitro studies evaluated the effect of endotoxin to alter GH secretion from dispersed sheep anterior pituitary cells at dosages of 1, 10 and 50 µg/ml, with samples collected at 4, 8 and 24 h. Endotoxin increased pituitary GH secretion at 24 h for 1 µg/ml (p < 0.05) and at all time periods for 10 and 50 µg/ml (p < 0.05). It also led to an increased release of ACTH and LH in vitro. The results of this study demonstrate the ability of endotoxin to alter pituitary hormone secretion both in vivo and in vitro in sheep, suggesting a direct effect of endotoxin on the pituitary gland." @default.
- W2090631820 created "2016-06-24" @default.
- W2090631820 creator A5013598761 @default.
- W2090631820 creator A5020949552 @default.
- W2090631820 creator A5032000434 @default.
- W2090631820 creator A5055586229 @default.
- W2090631820 creator A5076859110 @default.
- W2090631820 date "1993-01-01" @default.
- W2090631820 modified "2023-10-15" @default.
- W2090631820 title "Effect of Endotoxin on Pituitary Hormone Secretion in Sheep" @default.
- W2090631820 doi "https://doi.org/10.1159/000126520" @default.
- W2090631820 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8264844" @default.
- W2090631820 hasPublicationYear "1993" @default.
- W2090631820 type Work @default.
- W2090631820 sameAs 2090631820 @default.
- W2090631820 citedByCount "94" @default.
- W2090631820 countsByYear W20906318202012 @default.
- W2090631820 countsByYear W20906318202013 @default.
- W2090631820 countsByYear W20906318202014 @default.
- W2090631820 countsByYear W20906318202015 @default.
- W2090631820 countsByYear W20906318202016 @default.
- W2090631820 countsByYear W20906318202017 @default.
- W2090631820 countsByYear W20906318202018 @default.
- W2090631820 countsByYear W20906318202019 @default.
- W2090631820 countsByYear W20906318202020 @default.
- W2090631820 countsByYear W20906318202021 @default.
- W2090631820 countsByYear W20906318202023 @default.
- W2090631820 crossrefType "journal-article" @default.
- W2090631820 hasAuthorship W2090631820A5013598761 @default.
- W2090631820 hasAuthorship W2090631820A5020949552 @default.
- W2090631820 hasAuthorship W2090631820A5032000434 @default.
- W2090631820 hasAuthorship W2090631820A5055586229 @default.
- W2090631820 hasAuthorship W2090631820A5076859110 @default.
- W2090631820 hasConcept C126322002 @default.
- W2090631820 hasConcept C134018914 @default.
- W2090631820 hasConcept C150903083 @default.
- W2090631820 hasConcept C207001950 @default.
- W2090631820 hasConcept C2777658017 @default.
- W2090631820 hasConcept C2778575703 @default.
- W2090631820 hasConcept C2779029589 @default.
- W2090631820 hasConcept C2779064019 @default.
- W2090631820 hasConcept C2780546910 @default.
- W2090631820 hasConcept C49039625 @default.
- W2090631820 hasConcept C71315377 @default.
- W2090631820 hasConcept C71924100 @default.
- W2090631820 hasConcept C86803240 @default.
- W2090631820 hasConcept C94984642 @default.
- W2090631820 hasConceptScore W2090631820C126322002 @default.
- W2090631820 hasConceptScore W2090631820C134018914 @default.
- W2090631820 hasConceptScore W2090631820C150903083 @default.
- W2090631820 hasConceptScore W2090631820C207001950 @default.
- W2090631820 hasConceptScore W2090631820C2777658017 @default.
- W2090631820 hasConceptScore W2090631820C2778575703 @default.
- W2090631820 hasConceptScore W2090631820C2779029589 @default.
- W2090631820 hasConceptScore W2090631820C2779064019 @default.
- W2090631820 hasConceptScore W2090631820C2780546910 @default.
- W2090631820 hasConceptScore W2090631820C49039625 @default.
- W2090631820 hasConceptScore W2090631820C71315377 @default.
- W2090631820 hasConceptScore W2090631820C71924100 @default.
- W2090631820 hasConceptScore W2090631820C86803240 @default.
- W2090631820 hasConceptScore W2090631820C94984642 @default.
- W2090631820 hasIssue "1" @default.
- W2090631820 hasLocation W20906318201 @default.
- W2090631820 hasLocation W20906318202 @default.
- W2090631820 hasOpenAccess W2090631820 @default.
- W2090631820 hasPrimaryLocation W20906318201 @default.
- W2090631820 hasRelatedWork W1916395109 @default.
- W2090631820 hasRelatedWork W1978299924 @default.
- W2090631820 hasRelatedWork W2026865421 @default.
- W2090631820 hasRelatedWork W2029936739 @default.
- W2090631820 hasRelatedWork W2066115524 @default.
- W2090631820 hasRelatedWork W2081113007 @default.
- W2090631820 hasRelatedWork W2088879451 @default.
- W2090631820 hasRelatedWork W3159182833 @default.
- W2090631820 hasRelatedWork W4251123667 @default.
- W2090631820 hasRelatedWork W2108495350 @default.
- W2090631820 hasVolume "58" @default.
- W2090631820 isParatext "false" @default.
- W2090631820 isRetracted "false" @default.
- W2090631820 magId "2090631820" @default.
- W2090631820 workType "article" @default.