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• W2090633581 endingPage "1762" @default.
• W2090633581 startingPage "1755" @default.
• W2090633581 abstract "We have previously reported that in contrast to what has been described in adult lung, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] has specific binding sites in rat fetal lung at the end of gestation, and it stimulates in vitro the phospholipid biosynthesis and surfactant release from fetal rat type II pneumocytes. In the present study an immunohistochemical technique using a rat monoclonal antibody (9A7γ) and binding studies were carried out on fresh lung tissues from fetal and newborn rats during the perinatal period to identify the cell(s) directly responsive to 1,25-(OH)2D3 in fetal lung and to look for a down-regulation of the 1,25-(OH)2D3 receptors in the perinatal period. We also searched for a regulation of 1,25-(OH)2D3 binding to fetal lung by 1,25-(OH)2D3 itself and by factors known to affect lung maturation or be involved in parturition. Our results suggest that 1) fetal type II pneumocytes are target cells for 1,25-(OH)2D3; 2) a physiological down-regulation of the 1,25-(OH)2D3 receptors in rat lung occurs in the perinatal period, starting a few hours before birth and lasting at least up to the fifth day of life; and 3) the capacity of rat fetal lung to bind 1,25-(OH)2D3 can be modulated in vitro by different hormones; a small inhibitory effect is observed with oxytocin (100 μ/ml), while PRL (10-8 M), T4 (10-6-10-10M), 1,25-(OH)2D3 (10-9-10-10 M), and, to a lesser extent, dexamethasone (10-7 M) induce a 2- to 4-fold increase in the number of 1,25-(OH)2D3 receptors without altering the binding affinity of receptor for 1,25-(OH)2D3. (Endocrinology127: 1755–1762,1990)" @default.
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• W2090633581 date "1990-10-01" @default.
• W2090633581 modified "2023-10-03" @default.
• W2090633581 title "1,25-Dihydroxyvitamin D₃Receptors in Rat Lung during the Perinatal Period: Regulation and Immunohistochemical Localization" @default.
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• W2090633581 doi "https://doi.org/10.1210/endo-127-4-1755" @default.
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