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• W2090633693 abstract "Abstract The photodynamic inactivation of bacteriophage T 2 and oX-174 in the presence of proflavine has been investigated. The reaction has been shown to be photochemical in nature and has been interpreted in terms of the formation of a reversible complex between the DNA of the phage and the dye. The approximate dissociation constants for these complexes have been estimated at 3·10 −6 M for T2 and 3·10 −7 M oX-174. This binding is competitively reversed in the presence of aliphatic diamines with no particular specificity f chain length. The approximate dissociation constant for cadaverine is 3.5·10 −3 M for the DNA of either phage. Some preliminary observations concerning the structural requirements of other photodynamically active dyes are presented: methylene blue and acridine organge, which as bifunctional amines bear a close resemblance to proflavine, are active; 9-aminoacridine and riboflavin, both of which are otherwise photochemically effective, lack the necessary structuralbifunctionality and are inert as photodynamic sensitizers. A brief survey has also been made of the ability of proflavine to inactivate both bacteriophages in the dark. This effect resembles photodynamic inactivation with respect to the concentration dependence and the amount of dye required to achieve half-maximal saturation. Dark inactivation is prevented competitively by aliphatic diamines; no chain-length specificityis observed with oX-174, but T2 is maximally protected by cadaverine. In this reaction the amine serves in a function presumably analogous to that responsible for the protection against thermal inactivation of π, the protoplast-infecting agent derived from T2, and for the shift in melting temperature of isolated T2 DNA." @default.
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• W2090633693 date "1961-10-01" @default.
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• W2090633693 title "Studies in partially resolved bacteriophage-host systems VII. Diamines, Dyes, empty phage heads, and protoplast-infecting agent" @default.
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• W2090633693 doi "https://doi.org/10.1016/0006-3002(61)90808-3" @default.
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