FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090634239> ?p ?o ?g. }

• W2090634239 abstract "During spaceflight, organisms are subjected to mechanical force changes (gravity (G) changes) that affect the immune system. However, gravitational effects on lymphopoiesis have rarely been studied. Consequently, we investigated whether the TCRβ repertoire, created by V(D)J recombination during T lymphopoiesis, is affected by hypergravity exposure during murine development. To address this question, C57BL/6j mice were mated in a centrifuge so that embryonic development, birth and TCRβ rearrangements occurred at 2G. Pups were sacrificed at birth, and their thymus used to quantify transcripts coding for factors required for V(D)J recombination and T lymphopoiesis. We also created cDNA mini-libraries of TCRβ transcripts to study the impact of hypergravity on TCRβ diversity. Our data show that hypergravity exposure increases the transcription of TCRβ chains, and of genes whose products are involved in TCR signaling, and affects the V(D)J recombination process. We also observed that ~85% of the TCRβ repertoire is different between hypergravity and control pups. These data indicate that changing a mechanical force (the gravity) during ontogeny will likely affect host immunity because properties of loops constituting TCR antigen-binding sites are modified in hypergravity newborns. The spectrum of peptides recognized by TCR will therefore likely be different." @default.
• W2090634239 created "2016-06-24" @default.
• W2090634239 creator A5009754795 @default.
• W2090634239 creator A5012700214 @default.
• W2090634239 creator A5034084280 @default.
• W2090634239 creator A5039276492 @default.
• W2090634239 date "2015-03-20" @default.
• W2090634239 modified "2023-10-16" @default.
• W2090634239 title "Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn mice" @default.
• W2090634239 cites W135571511 @default.
• W2090634239 cites W1518648676 @default.
• W2090634239 cites W1545000407 @default.
• W2090634239 cites W154830979 @default.
• W2090634239 cites W1750187561 @default.
• W2090634239 cites W1898760839 @default.
• W2090634239 cites W1933637003 @default.
• W2090634239 cites W1975495128 @default.
• W2090634239 cites W1976464755 @default.
• W2090634239 cites W1979836429 @default.
• W2090634239 cites W1980624099 @default.
• W2090634239 cites W1995580336 @default.
• W2090634239 cites W1999056435 @default.
• W2090634239 cites W2015097042 @default.
• W2090634239 cites W2019060451 @default.
• W2090634239 cites W2021351245 @default.
• W2090634239 cites W2027259461 @default.
• W2090634239 cites W2028749270 @default.
• W2090634239 cites W2050986536 @default.
• W2090634239 cites W2054430911 @default.
• W2090634239 cites W2054963254 @default.
• W2090634239 cites W2063133063 @default.
• W2090634239 cites W2074255479 @default.
• W2090634239 cites W2080181628 @default.
• W2090634239 cites W2092053127 @default.
• W2090634239 cites W2096916192 @default.
• W2090634239 cites W2097007381 @default.
• W2090634239 cites W2099812795 @default.
• W2090634239 cites W2105273832 @default.
• W2090634239 cites W2132661305 @default.
• W2090634239 cites W2136746620 @default.
• W2090634239 cites W2137042254 @default.
• W2090634239 cites W2140489687 @default.
• W2090634239 cites W2143513209 @default.
• W2090634239 cites W2145653561 @default.
• W2090634239 cites W2153230724 @default.
• W2090634239 cites W2158344454 @default.
• W2090634239 cites W2159573770 @default.
• W2090634239 cites W2163683111 @default.
• W2090634239 cites W2167863101 @default.
• W2090634239 cites W2334809368 @default.
• W2090634239 cites W2402767209 @default.
• W2090634239 cites W2412374173 @default.
• W2090634239 cites W2426776444 @default.
• W2090634239 doi "https://doi.org/10.1038/srep09318" @default.
• W2090634239 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5380131" @default.
• W2090634239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25792033" @default.
• W2090634239 hasPublicationYear "2015" @default.
• W2090634239 type Work @default.
• W2090634239 sameAs 2090634239 @default.
• W2090634239 citedByCount "22" @default.
• W2090634239 countsByYear W20906342392016 @default.
• W2090634239 countsByYear W20906342392017 @default.
• W2090634239 countsByYear W20906342392018 @default.
• W2090634239 countsByYear W20906342392019 @default.
• W2090634239 countsByYear W20906342392020 @default.
• W2090634239 countsByYear W20906342392021 @default.
• W2090634239 countsByYear W20906342392022 @default.
• W2090634239 countsByYear W20906342392023 @default.
• W2090634239 crossrefType "journal-article" @default.
• W2090634239 hasAuthorship W2090634239A5009754795 @default.
• W2090634239 hasAuthorship W2090634239A5012700214 @default.
• W2090634239 hasAuthorship W2090634239A5034084280 @default.
• W2090634239 hasAuthorship W2090634239A5039276492 @default.
• W2090634239 hasBestOaLocation W20906342391 @default.
• W2090634239 hasConcept C104317684 @default.
• W2090634239 hasConcept C109159458 @default.
• W2090634239 hasConcept C113646796 @default.
• W2090634239 hasConcept C128709446 @default.
• W2090634239 hasConcept C156695909 @default.
• W2090634239 hasConcept C19317047 @default.
• W2090634239 hasConcept C203014093 @default.
• W2090634239 hasConcept C2776090121 @default.
• W2090634239 hasConcept C2779341262 @default.
• W2090634239 hasConcept C28328180 @default.
• W2090634239 hasConcept C54355233 @default.
• W2090634239 hasConcept C79904392 @default.
• W2090634239 hasConcept C86803240 @default.
• W2090634239 hasConcept C87355193 @default.
• W2090634239 hasConcept C8891405 @default.
• W2090634239 hasConcept C95444343 @default.
• W2090634239 hasConceptScore W2090634239C104317684 @default.
• W2090634239 hasConceptScore W2090634239C109159458 @default.
• W2090634239 hasConceptScore W2090634239C113646796 @default.
• W2090634239 hasConceptScore W2090634239C128709446 @default.
• W2090634239 hasConceptScore W2090634239C156695909 @default.
• W2090634239 hasConceptScore W2090634239C19317047 @default.
• W2090634239 hasConceptScore W2090634239C203014093 @default.
• W2090634239 hasConceptScore W2090634239C2776090121 @default.
• W2090634239 hasConceptScore W2090634239C2779341262 @default.
• W2090634239 hasConceptScore W2090634239C28328180 @default.

• next