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• W2090640982 abstract "The E-cadherin/catenin complex plays a major role in epithelial cell–cell adhesion. Both β-catenin and γ-catenin bind directly to the cytoplasmic domain of E-cadherin whereas α-catenin links the bound β-catenin or γ-catenin to the actin microfilament network of the cellular cytoskeleton. Significant changes in the expression and/or structure of members of the complex can occur in neoplasia. Several studies have reported on the nuclear localization of β- and γ-catenin and on their role in influencing the transcriptional activity of several proto-oncogenes. The cellular localization of α-catenin has not been studied in detail. The aim of this study was to investigate the cellular localization of α-catenin in colorectal carcinoma both in vitro and in vivo and to assess whether it might be relevant to tumor behavior. The expression of α-catenin was examined in a panel of colorectal carcinoma cell lines (SW480, SW620, HCT116, HT29, and Caco-2) using a combination of immunohistochemistry, confocal fluorescence microscopy, and Western blotting. The expression of α-catenin was also studied by immunohistochemistry in 15 sporadic colorectal adenomas, 30 sporadic colorectal adenocarcinomas, and their 13 lymph node metastases. From familial adenomatous polyposis patients, 20 adenomas and 5 adenocarcinomas were studied. Nuclear localization of α-catenin was detected in the colorectal carcinoma cell lines when the cells were dispersed rather than confluent. α-catenin was not detected in the nuclei in any of the sporadic or familial adenomas. However, it was detected in one sporadic and one familial adenocarcinoma but not in any of the lymph node deposits. α-catenin can localize to the nuclei of colorectal tumor cells, and this may be related to lack of perception of connection to adjacent cells." @default.
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• W2090640982 date "2002-09-01" @default.
• W2090640982 modified "2023-09-27" @default.
• W2090640982 title "Variable Nuclear Localization of α-Catenin in Colorectal Carcinoma" @default.
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• W2090640982 doi "https://doi.org/10.1097/01.lab.0000028821.41246.6a" @default.
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