FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090665327> ?p ?o ?g. }

• W2090665327 endingPage "122" @default.
• W2090665327 startingPage "111" @default.
• W2090665327 abstract "In addition to atrial natriuretic peptide (ANP99-126) itself, linear peptide fragments from its N-terminal prohormone segment (pro-ANP) have been reported to have biological activity. In vivo, diuresis and natriuresis, as well as hypotension have been observed. In vitro, sodium uptake into medullary collecting duct cells was inhibited, and tone of vascular smooth muscle was reduced, associated with activation of guanylate cyclase. Such previous studies have used heterologous peptides and species, e.g., human pro-ANP1-30 or pro-ANP31-67, tested in rat, pig, or dog. The present experiments were designed to test whether rat pro-ANP1-30 or pro-ANP31-67 were natriuretic and hypotensive in rats, whether the two peptides showed specific binding to plasma membranes from rat kidney cortex or aorta, and whether they affected particulate guanylate cyclase activity in rat glomerular membranes. To extend in vitro results from the literature, the effect of human pro-ANP31-67 on transport in the rat medullary collecting duct in vivo was also tested. Although rat ANP99-126, as expected, increased diuresis and natriuresis, associated with inhibition of transport in the medullary collecting duct, in identically treated rats human pro-ANP31-67 was without effect. Similarly, only the ANP99-126 infusion resulted in reduction of arterial blood pressure. Furthermore, no diuretic, natriuretic, or hypotensive responses were observed in rats infused with either rat pro-ANP31-67 or pro-ANP1-30. In plasma membranes from rat kidney cortex or aorta, neither of the rat prosegments showed specific binding, or interference with ANP99-126 receptors. Finally, in contrast to ANP99-126, neither of the prosegments was able to increase basal guanylate cyclase activity in rat glomerular membranes. Therefore, under our experimental conditions we were unable to replicate the earlier results. This study thus does not support a regulatory role for pro-ANP fragments in blood volume or blood pressure homeostasis." @default.
• W2090665327 created "2016-06-24" @default.
• W2090665327 creator A5022544197 @default.
• W2090665327 creator A5024211690 @default.
• W2090665327 creator A5063250891 @default.
• W2090665327 creator A5086376075 @default.
• W2090665327 date "1994-09-01" @default.
• W2090665327 modified "2023-10-15" @default.
• W2090665327 title "Lack of biologic activity or specific binding of amino-terminal pro-ANP segments in the rat" @default.
• W2090665327 cites W1518913349 @default.
• W2090665327 cites W1574096163 @default.
• W2090665327 cites W1971068518 @default.
• W2090665327 cites W1980945058 @default.
• W2090665327 cites W2002000738 @default.
• W2090665327 cites W2005459681 @default.
• W2090665327 cites W2006352708 @default.
• W2090665327 cites W2008775909 @default.
• W2090665327 cites W2013011084 @default.
• W2090665327 cites W2041084967 @default.
• W2090665327 cites W2044142393 @default.
• W2090665327 cites W2046799095 @default.
• W2090665327 cites W2052097767 @default.
• W2090665327 cites W2061705766 @default.
• W2090665327 cites W2066973770 @default.
• W2090665327 cites W2075489298 @default.
• W2090665327 cites W2088748862 @default.
• W2090665327 cites W2102131116 @default.
• W2090665327 doi "https://doi.org/10.1016/0167-0115(94)90612-2" @default.
• W2090665327 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7831500" @default.
• W2090665327 hasPublicationYear "1994" @default.
• W2090665327 type Work @default.
• W2090665327 sameAs 2090665327 @default.
• W2090665327 citedByCount "10" @default.
• W2090665327 countsByYear W20906653272013 @default.
• W2090665327 crossrefType "journal-article" @default.
• W2090665327 hasAuthorship W2090665327A5022544197 @default.
• W2090665327 hasAuthorship W2090665327A5024211690 @default.
• W2090665327 hasAuthorship W2090665327A5063250891 @default.
• W2090665327 hasAuthorship W2090665327A5086376075 @default.
• W2090665327 hasConcept C126322002 @default.
• W2090665327 hasConcept C134018914 @default.
• W2090665327 hasConcept C150903083 @default.
• W2090665327 hasConcept C170493617 @default.
• W2090665327 hasConcept C174459258 @default.
• W2090665327 hasConcept C185592680 @default.
• W2090665327 hasConcept C207001950 @default.
• W2090665327 hasConcept C2775915353 @default.
• W2090665327 hasConcept C2778069365 @default.
• W2090665327 hasConcept C2778198053 @default.
• W2090665327 hasConcept C2779547328 @default.
• W2090665327 hasConcept C2780091579 @default.
• W2090665327 hasConcept C2780512574 @default.
• W2090665327 hasConcept C71924100 @default.
• W2090665327 hasConcept C86803240 @default.
• W2090665327 hasConcept C8741621 @default.
• W2090665327 hasConceptScore W2090665327C126322002 @default.
• W2090665327 hasConceptScore W2090665327C134018914 @default.
• W2090665327 hasConceptScore W2090665327C150903083 @default.
• W2090665327 hasConceptScore W2090665327C170493617 @default.
• W2090665327 hasConceptScore W2090665327C174459258 @default.
• W2090665327 hasConceptScore W2090665327C185592680 @default.
• W2090665327 hasConceptScore W2090665327C207001950 @default.
• W2090665327 hasConceptScore W2090665327C2775915353 @default.
• W2090665327 hasConceptScore W2090665327C2778069365 @default.
• W2090665327 hasConceptScore W2090665327C2778198053 @default.
• W2090665327 hasConceptScore W2090665327C2779547328 @default.
• W2090665327 hasConceptScore W2090665327C2780091579 @default.
• W2090665327 hasConceptScore W2090665327C2780512574 @default.
• W2090665327 hasConceptScore W2090665327C71924100 @default.
• W2090665327 hasConceptScore W2090665327C86803240 @default.
• W2090665327 hasConceptScore W2090665327C8741621 @default.
• W2090665327 hasIssue "2" @default.
• W2090665327 hasLocation W20906653271 @default.
• W2090665327 hasLocation W20906653272 @default.
• W2090665327 hasOpenAccess W2090665327 @default.
• W2090665327 hasPrimaryLocation W20906653271 @default.
• W2090665327 hasRelatedWork W2024427298 @default.
• W2090665327 hasRelatedWork W2028696209 @default.
• W2090665327 hasRelatedWork W2073683436 @default.
• W2090665327 hasRelatedWork W2104046861 @default.
• W2090665327 hasRelatedWork W2322156960 @default.
• W2090665327 hasRelatedWork W2342385691 @default.
• W2090665327 hasRelatedWork W2409540958 @default.
• W2090665327 hasRelatedWork W2409606326 @default.
• W2090665327 hasRelatedWork W2414755357 @default.
• W2090665327 hasRelatedWork W616565072 @default.
• W2090665327 hasVolume "53" @default.
• W2090665327 isParatext "false" @default.
• W2090665327 isRetracted "false" @default.
• W2090665327 magId "2090665327" @default.
• W2090665327 workType "article" @default.