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- W2090666787 abstract "Zinc oxide nanoparticles (ZnO NPs) are commonly used in sunscreens to reduce the risk of skin cancer by blockingultraviolet radiation. ZnO NPs absorption through the transdermal route may not cause high health risk as inhalation oringestion. However, in practical usage of sunscreens and cosmetics, ZnO NPs are topically applied to a large area ofskin with long periods hence the potential absorption amount of ZnO NPs is still need to be concerned. Therefore, if theZnO NPs are able the pass the barrier of normal skin, the pathways of transdermal delivery and the factors ofenhancements become important issues. In this work, multiphoton microscopy provides us a non-invasive visualizationof ZnO NPs in skin. Moreover, we quantitatively analyzed the enhancement of oleic acid and ethanol.Due to the fact that photoluminance of ZnO NPs spectrally overlaps autofluorence from skin stratum corneum (SC) andhigh turbidity of both ZnO NPs and SC, it is difficult to resolve the distribution of ZnO NPs in skin by usingfluorescence microscopy. In this work, the second harmonic generation (SHG) signals from ZnO NPs which double thefrequency of excitation source to characterize the delivery pathways and penetration depth in skin. Moreover, wequantitatively compare the ZnO NPs delivery efficiency in normal skin and in skins with three chemically enhancingconditions: ethanol, oleic acid and the combination of ethanol and oleic acid." @default.
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- W2090666787 date "2010-02-11" @default.
- W2090666787 modified "2023-09-23" @default.
- W2090666787 title "Monitoring chemically enhanced transdermal delivery of zinc oxide nanoparticles by using multiphoton microscopy" @default.
- W2090666787 doi "https://doi.org/10.1117/12.843187" @default.
- W2090666787 hasPublicationYear "2010" @default.
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