Matches in SemOpenAlex for { <https://semopenalex.org/work/W2090695244> ?p ?o ?g. }
- W2090695244 endingPage "1730" @default.
- W2090695244 startingPage "1721" @default.
- W2090695244 abstract "Interactions between maternal natural killer lymphocytes (NKs) and fetal tissues are important in mediating maternal–fetal tolerance. We therefore investigated the interactions of NKs to placenta-derived multipotent cells (PDMCs) isolated from the term human placenta. PDMCs have similar cell surface marker expression as bone marrow mesenchymal stem cells (BMMSCs) and additionally express human embryonic stem cell markers SSEA-4 and CD-9. Differentiation into the tri-mesodermal lineages of osteoblastic, adipocytic, and chondrogenic phenotypes can be readily achieved under the appropriate conditions. We found that PDMCs are more resistant to NK-mediated lysis than the major histocompatibility complex (MHC) class-I null target cell K562, and can suppress NK secretion of interferon-γ (IFN-γ). Moreover, as third-party cells, PDMCs suppressed the cytotoxic effects of cytokine-stimulated NKs on K562. Pretreatment of PDMCs with IFN-γ, a proinflammatory cytokine, surprisingly enhanced such immunosuppressive effects. Cell–cell contact between NKs and PDMCs is required for suppressive effects, which are partially mediated by slight upregulation of the NK inhibitory receptor killer inhibitory receptor and downregulation of the activating receptor NKp30. Moreover, enhancement of PDMC suppressive effects is also mediated by IFN-γ-induced surface expression of HLA-G—an immunomodulatory nonclassical MHC class I molecule—on PDMCs, as seen by partial reversibility with HLA-G neutralizing antibodies. With its broad immunosuppressive properties, PDMCs may represent a potential cell source for therapeutic use." @default.
- W2090695244 created "2016-06-24" @default.
- W2090695244 creator A5009735945 @default.
- W2090695244 creator A5020240302 @default.
- W2090695244 creator A5029977917 @default.
- W2090695244 creator A5030795079 @default.
- W2090695244 creator A5034083957 @default.
- W2090695244 creator A5072353128 @default.
- W2090695244 creator A5075415677 @default.
- W2090695244 creator A5084147717 @default.
- W2090695244 creator A5084330883 @default.
- W2090695244 date "2011-12-01" @default.
- W2090695244 modified "2023-10-18" @default.
- W2090695244 title "Surface Expression of HLA-G is Involved in Mediating Immunomodulatory Effects of Placenta-Derived Multipotent Cells (PDMCs) towards Natural Killer Lymphocytes" @default.
- W2090695244 cites W1541698391 @default.
- W2090695244 cites W1593435314 @default.
- W2090695244 cites W1967824323 @default.
- W2090695244 cites W1975855149 @default.
- W2090695244 cites W1979253523 @default.
- W2090695244 cites W1980310807 @default.
- W2090695244 cites W1982408656 @default.
- W2090695244 cites W1989466512 @default.
- W2090695244 cites W1991328368 @default.
- W2090695244 cites W1993147375 @default.
- W2090695244 cites W1995499825 @default.
- W2090695244 cites W1997674744 @default.
- W2090695244 cites W2004593135 @default.
- W2090695244 cites W2006712783 @default.
- W2090695244 cites W2008375975 @default.
- W2090695244 cites W2008440336 @default.
- W2090695244 cites W2019495971 @default.
- W2090695244 cites W2021134616 @default.
- W2090695244 cites W2022275876 @default.
- W2090695244 cites W2024971445 @default.
- W2090695244 cites W2028369131 @default.
- W2090695244 cites W2030920153 @default.
- W2090695244 cites W2036810329 @default.
- W2090695244 cites W2042644816 @default.
- W2090695244 cites W2048835947 @default.
- W2090695244 cites W2064919073 @default.
- W2090695244 cites W2065860650 @default.
- W2090695244 cites W2068043688 @default.
- W2090695244 cites W2079265307 @default.
- W2090695244 cites W2088500471 @default.
- W2090695244 cites W2088513299 @default.
- W2090695244 cites W2095666785 @default.
- W2090695244 cites W2107652077 @default.
- W2090695244 cites W2112427544 @default.
- W2090695244 cites W2122107027 @default.
- W2090695244 cites W2138946470 @default.
- W2090695244 cites W2141633761 @default.
- W2090695244 cites W2143928630 @default.
- W2090695244 cites W2151517892 @default.
- W2090695244 cites W2155437011 @default.
- W2090695244 cites W2158829408 @default.
- W2090695244 cites W2160252640 @default.
- W2090695244 cites W80850850 @default.
- W2090695244 doi "https://doi.org/10.3727/096368911x580590" @default.
- W2090695244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21669042" @default.
- W2090695244 hasPublicationYear "2011" @default.
- W2090695244 type Work @default.
- W2090695244 sameAs 2090695244 @default.
- W2090695244 citedByCount "43" @default.
- W2090695244 countsByYear W20906952442013 @default.
- W2090695244 countsByYear W20906952442014 @default.
- W2090695244 countsByYear W20906952442015 @default.
- W2090695244 countsByYear W20906952442016 @default.
- W2090695244 countsByYear W20906952442017 @default.
- W2090695244 countsByYear W20906952442018 @default.
- W2090695244 countsByYear W20906952442019 @default.
- W2090695244 countsByYear W20906952442020 @default.
- W2090695244 countsByYear W20906952442021 @default.
- W2090695244 countsByYear W20906952442022 @default.
- W2090695244 countsByYear W20906952442023 @default.
- W2090695244 crossrefType "journal-article" @default.
- W2090695244 hasAuthorship W2090695244A5009735945 @default.
- W2090695244 hasAuthorship W2090695244A5020240302 @default.
- W2090695244 hasAuthorship W2090695244A5029977917 @default.
- W2090695244 hasAuthorship W2090695244A5030795079 @default.
- W2090695244 hasAuthorship W2090695244A5034083957 @default.
- W2090695244 hasAuthorship W2090695244A5072353128 @default.
- W2090695244 hasAuthorship W2090695244A5075415677 @default.
- W2090695244 hasAuthorship W2090695244A5084147717 @default.
- W2090695244 hasAuthorship W2090695244A5084330883 @default.
- W2090695244 hasConcept C154317977 @default.
- W2090695244 hasConcept C170627219 @default.
- W2090695244 hasConcept C202751555 @default.
- W2090695244 hasConcept C203014093 @default.
- W2090695244 hasConcept C207936829 @default.
- W2090695244 hasConcept C2778690821 @default.
- W2090695244 hasConcept C55493867 @default.
- W2090695244 hasConcept C86803240 @default.
- W2090695244 hasConcept C8891405 @default.
- W2090695244 hasConcept C95444343 @default.
- W2090695244 hasConceptScore W2090695244C154317977 @default.
- W2090695244 hasConceptScore W2090695244C170627219 @default.
- W2090695244 hasConceptScore W2090695244C202751555 @default.
- W2090695244 hasConceptScore W2090695244C203014093 @default.